 | | Vol. 5.04 – 1 February, 2024 |
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| Scientists established a colorectal cancer-derived organoid biobank and induced acquired drug resistance by repeated low-level exposures to chemo-agents.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established a human intestinal stem cell (ISC) culture method expanded under feeder-free and fully defined conditions through selective enrichment of ISC populations within human intestinal organoids derived from hiPSCs.
[Nature Communications] |
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| The authors reported success in long-term culture of 64 patient-derived hepatobiliary tumor organoids from a Chinese population.
[Cell Reports Medicine] |
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| Scientists used LEGO: Laboratory Engineered Glioblastoma-like Organoid, models and provided an unprecedented comprehensive characterization of LEGO models using single-cell transcriptome, DNA methylome, metabolome, lipidome, proteome, and phospho-proteome analysis.
[npj Precision Oncology] |
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| Investigators used a multidisciplinary approach combining microfluidics, organoids, and transcriptomics to identify molecular changes in angiogenic programs that impede the successful in vitro vascularization of hiPSC-derived cerebral organoids.
[Lab On A Chip] |
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| Researchers confirmed engrailed-1 (EN1) as a differential diagnostic marker for adenoid cystic carcinoma, and further investigated the regulatory mechanism and biological function of EN1 in tumor progression.
[International Journal of Cancer] |
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| To determine the role of SHROOM3 in early developmental morphogenesis, scientists established a neuroepithelial organoid culture system derived from cynomolgus monkeys to closely mimic the in vivo neural plate phase.
[Zoological Research] |
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| Investigators established the optimal conditions for coculturing N2a neuronal cells with murine salivary gland organoids.
[Laryngoscope] |
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| Researchers utilized single-cell transcriptional profiling to delineate responses of murine and human normal breast organoid systems to female hormones across evolutionary distinct species.
[Journal Of Mammary Gland Biology And Neoplasia] |
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| The authors introduce the current or promising recombinant proteins for thrombolysis therapy in ischemic stroke and highlight the promise and challenges of stem cells and cerebral organoids in stroke therapy.
[Stroke and Vascular Neurology] |
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| Scientists provide descriptions of bioengineered 3D tumor models, such as organoids and tumor-on-a-chip systems, focusing on thyroid, adrenal, and neuroendocrine tumors and how they have been and are being applied in the context of endocrine tumors.
[Endocrine-Related Cancer] |
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| University at Albany scientist Scott Tenenbaum has received $500,000 from the National Institute on Aging to study how aging brain cells shape the progression of Alzheimer’s disease and advance RNA technology that could inform new therapeutics to prevent and treat Alzheimer’s and related dementias.
[University at Albany (Newswise)] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | Human Technopole – Milan, Italy |
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| | reNEW – Copenhagen, Denmark |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University of Alberta – Edmonton, Alberta, Canada |
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