 | | Vol. 5.06 – 15 February, 2024 |
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| Bioorthogonal click chemistry was applied to display the first demonstration of multiplexed cyclic imaging of live and fixed patient-derived glioblastoma tumor organoids.
[Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used human iPSC-derived renal organoids, which recapitulated nephrogenesis, to investigate mechanisms controling renal mesenchymal-to-epithelial transition.
[Developmental Cell] |
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| Using single-cell transcriptomics, scientists evaluated how organoids derived from freshly isolated first-trimester trophoblasts or from established uman trophoblast stem cell lines reproduce developmental cell trajectories and transcriptional regulatory processes defined in vivo.
[Developmental Cell] |
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| Researchers investigated the potential of adeno-associated virus-mediated aryl hydrocarbon receptor interacting protein-like 1 (AIPL1) gene replacement therapy in two previously validated human retinal organoid models of Leber congenital amaurosis subtype 4 (LCA4).
[Molecular Therapy – Nucleic Acids] |
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| Organoid forming potentials of post-neoadjuvant systemic therapy residual disease were checked and compared with clinical approaches to estimate the recurrence risk.
[British Journal of Cancer] |
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| Using an advanced human heart organoid system, researchers simulated embryonic heart development under pregestational diabetes–like conditions. These organoids developed pathophysiological features including reactive oxygen species-mediated stress and cardiomyocyte hypertrophy.
[Stem Cell Reports] |
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| Utilizing a novel kidney organoid model with enhanced proximal tubule maturity, genetic- and drug-mediated inhibition of viral entry and processing factors confirmed the requirement for ACE2 for SARS-CoV-2 entry.
[Journal Of Virology] |
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| Investigators used human stem cell-derived lung organoids as a model system to investigate the interaction of SARS-CoV-2 replication compartment proteins NSP3 and NSP4 with the mitochondrial network.
[Biophysical Journal] |
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| Scientists used CRISPR engineering to fuse a HaloTag domain to endogenous PIEZO1 in a hiPSC line. As a control, they generated isogenic PIEZO1-HaloTag knockout hiPSCs.
[Biophysical Journal] |
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| The authors highlight key insights that have been contributed by organoid models to virus research, the limitations that exist in current platforms, and outline novel approaches that are being applied to address these shortcomings.
[npj Viruses] |
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| Scientists highlight the importance of studying the neurovascular unit in a forward-looking perspective of leveraging their use for understanding and treating neurological disorders.
[Molecular Neurobiology] |
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| Universities must declare all their retractions and launch investigations into misconduct cases; a Nature analysis reveals that since 2021 there have been more than 17,000 Chinese co-authored retractions.
[Nature News] |
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| April 22 – 25, 2024
Baltimore, Maryland, United States |
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| | Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Human Technopole – Milan, Italy |
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