 | | Vol. 5.07 – 22 February, 2024 |
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| Investigators presented a method for generating complex bone marrow-like organoids (BMOs) from hiPSCs. BMOs consisted of cell types that self-organized into three-dimensional structures mimicking cellular, structural, and molecular characteristics of the hematopoietic microenvironment.
[Nature Methods] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated early stages of human thalamus development using hiPSC-derived organoids and showed that the 22q11.2 microdeletion underlied widespread transcriptional dysregulation associated with psychiatric disorders in thalamic neurons and glia.
[Cell Stem Cell] |
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| The authors developed a platform to establish and monitor the formation of endothelial networks around mesenchymal and pancreatic islet spheroids, as well as blood vessel organoids generated from PSCs, cultured for up to 30 days on-chip.
[Nature Communications] |
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| Researchers showed that folate receptor 1 was necessary for the formation of neural tube-like structures in human-cell derived neural organoids.
[Nature Communications] |
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| Given species differences in brain thyroid hormone transporters and the limitations of studies in mice, scientists generated brain organoids using human iPSCs from MCT8-deficient patients.
[JCI Insight] |
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| Researchers performed human neural organoids from iPSC-derived progenitor cells in two distinct formats: (i) cells seeded on a Matrigel surface; and (ii) cells seeded on a synthetic polyethylene glycol hydrogel surface.
[Journal of Tissue Engineering] |
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| Investigators developed and characterized adult stem cell-derived turtle liver organoids from painted, snapping, and spiny softshell turtles spanning ~175My of evolution, with a subset cryopreserved.
[Communications Biology] |
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| Scientists established a culture system using chicken organoids and characterized the organoids at passages 1 and 10.
[Journal of Animal Science and Biotechnology] |
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| The authors utilized MPRAs in stem cells and forebrain organoids to evaluate the activity of ~ 7000 gene-linked enhancers previously identified in human fetal tissues and brain organoids.
[Scientific Reports] |
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| Investigators summarize recent advancements in patient-derived organoids (PDO) development and the enhancement of PDO culture models.
[Advanced Healthcare Materials] |
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| The Korea Institute of Standards and Science (KRISS) has developed an organoid culture method that can accurately assess the toxicity of nanomaterials on the human body.
[Korea IT Times] |
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| April 24 – 26, 2024
Vienna, Austria |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Human Technopole – Milan, Italy |
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