 | | Vol. 5.08 – 29 February, 2024 |
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| The authors described an organoid culture method for cultivating patient-derived lymphoma organoids, which included cells from the native follicular lymphoma tumor microenvironment.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The transcriptomic and chromatin accessibility landscapes of matched colorectal cancer patient-derived organoids (PDO), patient-derived xenografts (PDX), PDO-derived PDX, and original patient tumors were compared. Two major remodeling axes were discovered.
[Advanced Science] |
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| A type of direct breast cancer cells–tumor-associated macrophages (TAMs) coculture organoid model was well developed by a sequential culture method in this study. Alginate cryogels were fabricated with appropriate physical and mechanical properties to serve as an alternative extracellular matrix.
[ACS Applied Materials & Interfaces] |
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| Researchers explored organoid culture recipes to capture tumor features of colorectal cancers. They found that the activation of Wnt and EGF signaling and inhibition of BMP signaling were non-essential for the survival of most colorectal cancer organoids.
[Cancer Letters] |
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| The authors presented paired 3D organoid cell lines of CWH22 and CLM22 with sound background information and the short tandem repeats were identical to those of the normal tissue.
[Aging-Us] |
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| Human embryonic stem cell-derived chambered cardiac organoid was used as a model system to study the effects of mesenchymal stem cell (MSC)-derived small extracellular vesicles on myocardial ischemia-reperfusion injury (IRI).
[Stem Cells] |
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| Investigators used cerebellar organoids differentiated from hiPSCs combined with CRISPR/Cas9 gene editing to investigate the earliest molecular and cellular consequences of Patched 1 (PTCH1) mutations on human cerebellar development.
[Disease Models & Mechanisms] |
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| Scientists examined the relationship between the clinical signs of oxaliplatin-induced liver injury and the responses of patient-derived liver organoids in vitro.
[Cancer Medicine] |
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| Researchers presented the techniques for isolating and culturing primary bovine endometrial epithelial cells and producing endometrial organoids.
[Theriogenology] |
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| The authors contrast advantages and disadvantages of each of these six cell-based methodologies. Neuronal-like cells derived from pluripotent monocytes are presented in more detail as this technique was recently used in psychiatry for the first time.
[Translational Psychiatry] |
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| Scientists introduce recent progress in the production methods of lung organoids, strategies for improving maturity, functionality, and complexity of organoids, and their application in disease modeling, including respiratory infection and pulmonary fibrosis.
[Journal of Tissue Engineering] |
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| Investigators underscore the potential benefits of microgravity on fundamental stem cell properties, highlighting the adaptability of cells to their environment and emphasizing physical stimuli as a key factor influencing cultured cells.
[Stem Cells And Development] |
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| The University of California, Irvine (UCI) received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center.
[UCI News] |
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| | The Institute of Genetics, Molecular and Cellular Biology – Strasbourg-Ville, France |
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| | Luxembourg Centre for Systems Biomedicine – Esch-sur-Alzette, Luxembourg |
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| | Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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