 | | Vol. 5.10 – 14 March, 2024 |
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| Using single-cell analysis, scientists characterized the cellular identities present in human amniotic fluid. They identified and isolated viable epithelial stem/progenitor cells of fetal gastrointestinal, renal, and pulmonary origin.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated how naive colon cancer organoids that were engineered in vitro to harbor Apc-null, KrasG12D and Trp53-null mutations adapted to the in vivo native colonic environment.
[Nature] |
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| Quality-controlled proliferating human hepatocytes (ProliHHs) were produced in mass and engineered as liver organoids to improve their maturity. Encapsulated ProliHHs liver organoids were intraperitoneally transplanted to treat liver failure animals.
[Cell Stem Cell] |
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| Researchers investigated the use of JAK inhibitors for anti-cancer activity in colorectal cancer cell lines, mouse model organoids and patient-derived organoids.
[Journal Of Experimental & Clinical Cancer Research] |
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| Investigators established patient-derived tumoroids from biobanked tissue samples of advanced high-grade gastroenteropancreatic neuroendocrine neoplasms patients and applied this model for targeted rapid ex vivo pharmacotyping, next-generation sequencing, and perturbational profiling.
[NPJ Precision Oncology] |
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| Scientists presented a strategy to generate liver organoids (LOs) containing Kupffer cells by recapitulating fetal liver hematopoiesis using iPSC-derived erythro-myeloid progenitors, the origin of tissue-resident macrophages, and hiPSC-derived LOs.
[Cell Reports] |
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| With the C9orf72 amyotrophic lateral sclerosis (ALS) patient-derived iPSCs and isogenic controls, researchers used an neuromuscular organoid (NMO) system containing trunk spinal cord neural and peripheral muscular tissues to show that the ALS NMOs could model peripheral defects in ALS.
[Cell Reports] |
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| Murine intestinal organoids were used to evaluate embedding in gelatin, carboxymethylcellulose (CMC)-gelatin-CMC-sucrose, or hydroxypropyl methylcellulose and polyvinylpyrrolidone solutions.
[Analytical Chemistry] |
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| Investigators treated pancreatic tumor organoids with 4 or 8 Gy of radiation, 10 μM of 5-fluorouracil, and 100 μM 3-bromopyruvate, a promising anti-cancer drug, as a single treatment modalities, and in combination with RT.
[Cell Death Discovery] |
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| Researchers generated long-term cultures of cortical brain organoid slices grown at the air-liquid interphase from regionalized cortical organoids.
[iScience] |
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| Investigators examine the contributions that hepatic organoids have made to three areas of liver research: as a source of cells and tissue for basic research, for drug discovery and drug safety testing, and for understanding disease pathobiology.
[Liver International] |
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| The authors review different approaches to analyze thousands of retinal organoids with currently available technologies and point to challenges that still await to be overcome both in culture and analysis of retinal organoids.
[Cold Spring Harbor Perspectives In Medicine] |
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| Research that involves creating “mini-organs” from human cells, including those from fetuses, may leave people uncomfortable – so the best approach is to explain the reasoning behind the work and its potential benefits.
[NewScientist] |
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| April 12 – 13, 2024
Barcelona, Spain |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | The Institute of Genetics, Molecular and Cellular Biology – Strasbourg-Ville, France |
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| | Luxembourg Centre for Systems Biomedicine – Esch-sur-Alzette, Luxembourg |
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| | Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States |
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