 | | Vol. 5.11 – 21 March, 2024 |
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| Scientists presented a novel cochlear organoids integrated conductive hydrogel biohybrid system with cochlear implant electroacoustic stimulation for cochlea-on-a-chip construction and high-throughput drug screening.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers described engineering strategies and alternative biocompatible materials that could facilitate the practical applications of organoids in regenerative medicine.
[Advanced Drug Delivery Reviews] |
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| Scientists established a microglia-incorporated human cerebral organoid model carrying an SCN2A protein-truncating mutation identified in children with autism spectrum disorder. They found that human microglia display increased elimination of post-synapse in cerebral organoids carrying the SCN2A mutation.
[Molecular Psychiatry] |
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| Investigators used CRISPR base editors to introduce different F-box and WD repeat domain-containing 7 (FBXW7) hotspot mutations in human colon organoids.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| | Lung tissues were collected from mice for mouse lung organoid construction. Alveolar macrophages derived from bronchoalveolar lavage and interstitial macrophages (IMs) derived from lung tissue were co-cultured, with novel matrigel-spreading lung organoids to construct an in vitro model of lung organoids–immune cells. |
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| | Researchers investigated the mechanisms of chlorpromazine (CPZ)-induced bile duct injury using advanced in vitro cholangiocyte cultures. Intrahepatic cholangiocyte organoids were driven into mature cholangiocyte-like cells which were exposed to CPZ under cholestatic or non-cholestatic conditions. |
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| Investigators used their recently developed 3D dendritic cell (DC)-tumor co-culture system to investigate how patient-derived primary and metastatic colorectal cancer organoids modulated conventional DC type 2 (cDC2) phenotype and function.
[European Journal Of Immunology] |
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| Scientists investigated potential CMV pathogenetic mechanisms of fetal neural malformation using in vitro human cerebral organoids. Cerebral organoids were permissive to CMV replication, and infection dysregulated cellular pluripotency and differentiation pathways.
[Communications Biology] |
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| | Investigators presented OrgaSegment, a MASK-RCNN based deep-learning segmentation model allowing for the segmentation of individual intestinal patient-derived organoids structures from bright-field images. |
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| Hypoxia-induced necrosis and delayed revascularization attenuate organoid viability and functional capacity, alleviated by the integration of diverse cell types e.g., human amniotic epithelial cells and human umbilical vein endothelial cells to boost vascularization.
[Life Sciences] |
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| To democratize access to lab-grown organ-like structures known as organoids and other advanced stem cell and transcriptomic technologies, USC will launch the CIRM ASCEND Center, dedicated to “Advancing Stem Cell Education and Novel Discoveries.”
[Keck School of Medicine of USC] |
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| April 24 – 26, 2024
Vienna, Austria |
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| | EPFL – Lausanne, Switzerland |
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| | University of Montpellier – Montpellier, France |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | The Institute of Genetics, Molecular and Cellular Biology – Strasbourg-Ville, France |
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