 | | Vol. 5.13 – 4 April, 2024 |
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| Using cerebral organoids, organotypic culture of human brain explants from individuals without COVID-19, and post-mortem brain samples from individuals with COVID-19, investigators found that neural cells were permissive to SARS-CoV-2 to a low extent.
[Nature Microbiology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators employed organoid technology as a promising new model for studying emerging pathogens and their pathogenic mechanisms. They investigated the key host-virus interaction patterns of five human coronaviruses in different human respiratory organoids.
[Emerging Microbes & Infections] |
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| Researchers expanded their current understanding of these differences in parechovirus A3 (PeV-A) central nervous system (CNS) disease using human brain organoids and clinical isolates of the two PeV-A genotypes.
[Nature Communications] |
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| Scientists exposed the engineered osteoarthritic cartilage organoids to factors known to attenuate pathological features, including IL-1Ra, and carried out mass spectrometry-based proteomics.
[Biomaterials] |
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| Researchers established a gut epithelium-microbe-immune microphysiological system to maintain the long-term continuous co-culture of Faecalibacterium prausnitzii/Faecalibacterium duncaniae with colonic epithelium, antigen-presenting cells, and CD4+ naive T cells circulating underneath the colonic epithelium.
[NPJ Biofilms And Microbiomes] |
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| Investigators reported the development of an estrogen receptor-positive (ER+) breast tumor organoid medium that conserved ER expression, estrogen responsiveness, and dependence, as well as sensitivity to endocrine therapy of ER+ patient-derived xenograft organoids
[Breast Cancer Research] |
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| Scientists identified two distinct morphological subtypes across 31360 bright field images using image-based profiling, which correlated differently with viability and apoptosis level of colorectal cancer organoids.
[Computers In Biology And Medicine] |
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| To identify potential intestinal carcinogens, investigators developed a cell transformation assay using mouse adult stem cell-derived intestinal organoids and assessed the transformation potential on 14 representative chemicals, including aspirin and metformin.
[Archives Of Toxicology] |
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| Long-term mesothelioma patient-derived organoids were established from ten malignant pleural effusion fluids. Mesothelioma patient-derived organoids were compared to the corresponding biopsy tissue specimens using immunohistochemistry labeling.
[Lung Cancer] |
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| Scientists explore the evolution of cancer organoids and emphasize the significant role these models play in fundamental research and the advancement of personalized medicine in oncology.
[Stem Cell Reviews And Reports] |
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| Scientists evaluate the current state-of-the-art regarding in vitro cell culture models of dental epithelium and ameloblast lineage with a particular focus toward their applicability for translational tissue engineering and regenerative/personalized medicine.
[Stem Cell Reviews and Report] |
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| The authors cover research focused on alveolar epithelial cells and discuss methods expected to regenerate lungs that are damaged by diseases.
[Stem Cells] |
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| Mammary organoids derived from mouse embryonic stem cells could offer clues into mammary gland developmental origins and help researchers study breast cancer.
[TheScientist] |
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| Arizona State University’s Mehdi Nikkhah was inducted as a fellow into the American Institute for Medical and Biomedical Engineering for his outstanding contributions to the engineering of biomimetic tissue-on-chip technologies and organoids for disease modeling and regenerative medicine.
[Arizona State University] |
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| April 17 – 19, 2024
London, England, United Kingdom |
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| | EPFL – Lausanne, Switzerland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Sapienza University – Rome, Italy |
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| | Umeå University – Umeå, Sweden |
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| | University of Kentucky – Lexington, Kentucky, United States |
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