 | | Vol. 5.14 – 11 April, 2024 |
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| Using a Muc6 knockout mouse model, gastric organoids, and cell lines, the authors proposed that Golgi stress responses and aberrant glycans induced by mucin deletion were important drivers of gastric cancer.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established hPSCs in allelic series representing four common nonsense mutations, using CRISPR base editing.
[Cell Stem Cell] |
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| Scientists developed a high-intensity ultrasound platform to inflict mechanical injury to iPSC-derived cortical organoids.
[Cell Stem Cell] |
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| Researchers developed an extracellular vesicle isolation pipeline from small volumes of human milk and neonatal intestinal contents after milk feeding to address the hypothesis that human milk contains extracellular vesicles survive in vivo neonatal digestion to be taken up intestinal epithelial cells.
[Journal of Extracellular Vesicles] |
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| By activating the STAT3 signaling pathway using leukemia inhibitory factor, the authors defined a cortical organoid differentiation method from hPSCs that recapitulated the expansion of a progenitor pool into the outer subventricular zone.
[Cell Reports] |
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| Scientists investigated the effect of trastuzumab monotherapy and its combination with different human epidermal growth factor receptor 2 (HER2) targeting treatments in a panel of breast cancer cell lines and patient-derived organoids using biochemical methods and cell viability assays.
[British Journal Of Cancer] |
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| Researchers investigated the cytotoxic anti-tumor effect of high-dose, short-term tyrosine kinase inhibitor treatment on five patient-derived tumor organoids.
[BJC Reports] |
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| The authors focused on in vitro modeling and therapeutic target finding of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary stroke disorder caused by mutations in the NOTCH3 gene.
[Molecular Neurobiology] |
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| Because the derivation of retinal organoids and transplantation is frequently split between geographically distant locations, investigators developed a special shipping device and protocol capable of the organoids’ delivery to any location.
[Stem Cells And Development] |
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| Secretion of vascular endothelial growth factor-A was analyzed to compare the proangiogenic properties of oral squamous cell carcinoma cells and corresponding cancer-associated fibroblasts.
[Oral Diseases] |
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| The authors summarize the methodology, the problems, and the solutions in lung cancer organoids generation, its application and limitations, as well as propose future challenges and perspectives.
[Translational Lung Cancer Research] |
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| A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional ‘miniature liver’. The procedure marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.
[Nature] |
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| May 3 – 7, 2024
Chicago, Illinois, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | EPFL – Lausanne, Switzerland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Sapienza University – Rome, Italy |
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| | University of Kentucky – Lexington, Kentucky, United States |
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