 | | Vol. 5.15 – 18 April, 2024 |
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| To understand the mechanistic significance of inter-regional projections on the development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists explored the potential of a composite hydrogel mainly consisting of calcium silicate nanowires and methacrylated gelatin as a substrate for organoid formation and functionalization, specifically for intestinal and liver organoids.
[Materials Horizons] |
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| Researchers investigated the effect of trastuzumab monotherapy and its combination with different HER2 targeting treatments in a panel of breast cancer cell lines and patient-derived organoids using biochemical methods and cell viability assays.
[British Journal Of Cancer] |
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| Scientists aimed to characterize the effect of calprotectin on mouse jejunal organoids as a model epithelium, focusing on Zn2+ metabolism and cell proliferation.
[Biomedicine & Pharmacotherapy] |
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| Researchers provided evidence that bazedoxifene inhibited tumour growth. Bazedoxifene combined with chemotherapy synergistically reduced cell proliferation and induced apoptosis in patient-derived colon cancer organoids.
[Cell Death Discovery] |
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| To identify how mutations in RFX6 impacted intestinal patterning and function, investigators derived iPSCs from this patient to generate human intestinal organoids.
[Development] |
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| The effects of lysophosphatidic acid (LPA)5 on intestinal stem cells were corroborated by studies using organoids derived from Lgr5-lineage tracking reporter mice with deletion of Lpar5 in Lgr5+-stem cells.
[American Journal Of Physiology-Gastrointestinal And Liver Physiology] |
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| Researchers generated and characterized several human-induced pluripotent stem cell lines from healthy human donor skin fibroblast cells. hiPSCs were then used for the generation of microglia-containing human cerebral organoids.
[Journal Of Neurovirology] |
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| Investigators examined the effects of EGFR and COX pathway inhibition in organoid cultures derived from uninvolved colon and polyps of serrated polyposis syndrome patients.
[Familial Cancer] |
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| Beginning with the basic concepts of organoids, the authors describe strategies for cultivating engineered organoids and discuss the multiple engineering modes to create conditions for breakthroughs in organoid research.
[Biomaterials Research] |
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| Researchers provided an overview of how intestinal organoids are being co-cultured with immune cells leading to substantial advances in our understanding of immune–epithelial interactions in the gut.
[Clinical & Experimental Immunology] |
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| A new development, termed fetal brain organoids or FeBOs, offers an unprecedented opportunity to study the intricate processes of early brain development. However, it also raises complex ethical and legal questions that demand careful consideration.
[Brain Tomorrow] |
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| May 7-11, 2024
Baltimore, Maryland, USA |
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| | Aarhus University – Aarhus, Denmark |
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| | Harvard Medical School and Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | EPFL – Lausanne, Switzerland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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Cancer Stem Cell News
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