 | | Vol. 5.16 – 25 April, 2024 |
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| Scientists developed antisense oligonucleotides (ASOs) to effectively decrease the inclusion of exon 8A in human cells. They discovered that the ASO-mediated switch from exon 8A to 8 robustly rescued defects in patient-derived cortical organoids and migration in forebrain assembloids.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed topobiologically complex mini-colons that were able to undergo tumorigenesis ex vivo by integrating microfabrication, optogenetic, and tissue engineering approaches.
[Nature] |
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| The authors utilized islet organoids derived from hESCs, animal models, and COVID-19 patients to discover that fibroblast growth factor 7 (FGF7) enhanced ACE2 expression within the islets, facilitating SARS-CoV-2 infection and resulting in impaired insulin secretion.
[Signal Transduction And Targeted Therapy] |
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| Bioprinted scaffolds facilitated the long-term cultivation and progressive maturation of extensive bioprinted bone organoids, foster multicellular differentiation, and offered valuable insights into the initial stages of bone formation.
[Advanced Materials] |
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| Using colorectal cancer patient-derived organoids, investigators found that compared to leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)- cells, LGR5+ cancer stem cells were stiffer, adhered better to the extracellular matrix, moved slower as single cells and clusters, and showed a higher survival rate.
[Nature Communications] |
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| Researchers used intestinal epithelial cells- and intestinal stem cells-specific claudin-7 (Cldn-7) knockout mice to investigate the regulatory effects of Cldn-7 on colonic Lgr5+ stem cells in the mediation of colonic epithelial injury and repair under physiological and inflammatory conditions.
[Cell Death & Disease] |
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| Scientists demonstrated the molecular architecture of borderline resectable pancreatic ductal adenocarcinoma (PDAC) manifested cancer dissemination of PDAC. 36 organoids isolated from primary tumor masses of PDAC patients with diverse metastatic statues were presented.
[Cellular Oncology] |
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| Investigators described an INTERaction with Organoid-in-MatriX model system, that presented a 3D co-culture-based platform for investigating matrix-dependent cellular crosstalk. They described its potential to uncover new molecular mechanisms of T cell responses to murine KPC pancreatic ductal adenocarcinoma.
[Scientific Reports] |
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| Scientists focused on stem cell related methodologies, such as organoids, that could serve as an alternative to animal testing and discuss its advantages and limitations, alongside regulatory considerations.
[Stem Cell Reviews And Reports] |
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| Researchers in Canada got most of what they were hoping for in the country’s 2024 federal budget, with a big boost in postgraduate pay and more funding for research and scientific infrastructure.
[Nature] |
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| May 20, 2024
New York, New York, United States & Online |
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| | University of Miami – Miami, Florida, United States |
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| | Aarhus University – Aarhus, Denmark |
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| | Harvard Medical School and Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
