 | | Vol. 2.14 – 15 April, 2021 |
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| Scientists systematically destabilized the IL-22–IL-10Rβ binding interface to create partial agonist analogs that decoupled downstream STAT1 and STAT3 signaling.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used human brain organoids to study the mechanisms underlying microcephaly caused by Zika virus and herpes simplex virus.
[Cell Stem Cell] |
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| The authors describe a long-term culturing protocol for ecto- and endocervical epithelia that generated 3D organoids that stably recapitulated the two tissues of origin.
[Cell Stem Cell] |
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| Scientists report forkhead box protein A1 (FOXA1) as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which methylates FOXA1 at lysine-295.
[Science Advances] |
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| In syngeneic mouse colorectal cancer (CRC) models and human patient-derived CRC organoid models, atractylenolide I treatment promoted the cytotoxicity of CD8+ T cells and thus profoundly enhanced the efficacy of immune checkpoint blockade therapy.
[Journal of Clinical Investigation] |
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| Through a series of studies spanning in vitro efferocytosis, ex vivo intestinal organoids, and in vivo Cre-mediated deletion of Paneth cells, researchers showed that Paneth cells mediated apoptotic cell uptake of dying neighbors.
[Current Biology] |
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| Scientists used human patient induced pluripotent stem cell (iPSC)-derived neural progenitor cells and organoids to model neurogenesis in fragile X syndrome.
[Cell Reports] |
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| Utilizing primary human duodenal organoids as in vitro models of the functional gastrointestinal epithelium, investigators found that Amiloride and NS-1619 presented significant effects in 223Ra membranal transport.
[Journal of Nuclear Medicine] |
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| Using airway organoid media developed by the Clevers laboratory, scientists succeeded in generating three lung tumoroid lines for long-term culture from 41 lung cancer cases.
[npj Precision Oncology] |
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| The authors report that propagating SARS-CoV-2 on the human airway cell line Calu-3 prevented cell culture adaptations in the multibasic cleavage sites. Similar results were obtained using a human airway organoid-based culture system for SARS-CoV-2 propagation.
[eLife] |
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| Time-lapse studies of organoids from Trpm5GFP:Gpr64mCherry mice revealed sequential expression of initially Trpm5GFP and subsequently also Gpr64mCherry in maturing intestinal tuft cells.
[Molecular Metabolism] |
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| Scientists report that SARS-CoV-2 productively infects both proximally and distally patterned human induced pluripotent stem cell-derived intestinal organoids, leading to the release of infectious viral particles while stimulating a robust transcriptomic response, including a significant upregulation of interferon-related genes that appeared to be conserved across multiple epithelial cell types.
[Stem Cell Reports] |
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| Investigators examined liquid culture cancer spheroids for the acquisition of apical‐basal polarity, sensitivity to an Akt inhibitor and interaction with extracellular matrix.
[FEBS Journal] |
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| The authors review and provide a pooled analysis of the results regarding the use of patient-derived organoids in individualized tumor response testing, focusing on evidence for analytical validity, clinical validity and clinical utility.
[npj Precision Oncology] |
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| Cytovia Therapeutics, Inc.announced that it has filed two provisional composition of matter patent applications for its FLEX-NK® platform, consisting of NKp46-based NK cell engager multifunctional antibodies targeting GPC3 for the treatment of solid tumors, including hepatocellular carcinoma, and CD38 for the treatment of hematological malignancies, including multiple myeloma.
[Cytovia Therapeutics, Inc.] |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Technische Universität Dresden – Dresden, Germany |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Helmholtz Association – Tübingen, Germany |
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| | Gladstone Institute – San Francisco, California, United States |
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