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| Using 3D cultures of human pluripotent stem cells, the authors sought to replicate key differentiation cues of cochlear specification. They found that timed modulations of Sonic Hedgehog and WNT signaling promoted ventral gene expression in otic progenitors.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified effective combinations of experimental small molecules with cold gas plasma for therapy in dermato-oncology. The combination effects of selected drugs and cold gas plasma were investigated with respect to oxidative stress, invasion, and viability.
[Journal of Advanced Research] |
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| Researchers bioprinted a model with two distinct regions containing gastric cancer patient-derived organoids and tumor-infiltrated lymphocytes.
[ACS Applied Materials & Interfaces] |
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| Investigators quantified the spatial and dynamic behavior of dendritic Golgi and endosomes during differentiation of human neurons generated from iPSCs. They revealed dynamic, functional Golgi structures in dendrites and a spatial map for investigating dendrite trafficking in human neurons.
[Cell Reports] |
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| Researchers examined extracellular matrix (ECM) modifications to elucidate the mechanism underlying carcinoma ex pleomorphic adenoma tumorigenesis. RNA-sequencing and bioinformatic analysis of organoids showed that differentially expressed genes were highly enriched in ECM-associated terms.
[Cell & Bioscience] |
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| Human colon organoids were maintained in a control culture medium alone or exposed to lipopolysaccharide with a combination of three pro-inflammatory cytokines to mimic the environment in the inflamed colon.
[Frontiers In Cell And Developmental Biology] |
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| Investigators modified previous protocols to generate more mature cerebellar organoids that allow for the establishment of several classes of mature neurons during cerebellar differentiation and development.
[Human Molecular Genetics] |
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| The authors used human cortical organoids from different donors to identify cell-type-specific developmental events that were affected by heterozygous mutations in PTEN.
[Human Molecular Genetics] |
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| Scientists investigated the biological significance of peripheral neurons in the formation of colonic organoids. Colonic organoids were co-cultured with hESC-derived peripheral neurons, resulting in the morphological maturation of columnar epithelial cells.
[International Journal of Stem Cells] |
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| The authors focus, firstly, on the limitations of existing immunotherapies for solid tumours, secondly, on how in vitro 3D immuno-oncology models are established using various technologies and thirdly, on the applications of these 3D models for comprehending the cancer.
[Nature Reviews Immunology] |
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| Investigators discuss the applications of brain organoids in studying preterm birth-associated brain dysfunction; viral infections-mediated neuroinflammation, neurodevelopmental, and neurodegenerative diseases.
[Cell Death Discovery] |
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| The UK Rare Disease Research Platform has been established with a £14 million investment over five years by the Medical Research Council and the National Institute for Health and Care Research.
[UK Research and Innovation] |
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| September 22 – 24, 2023
Ribeirao Preto, Brazil |
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| | Institute of Biology Valrose – Nice, France |
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| | ForÂschungsÂzentrum Jülich – Jülich, Germany |
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| | The National University of Singapore – Singapore, Singapore |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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