Pancreatic Cell News 10.03 January 29, 2019 | |
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TOP STORYLIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) promoted HIF1A protein translation by activating AKT/mTOR signaling, while HIF1 transactivated LIMS1 transcription, thus forming a positive feedback loop in PDAC cell adaptation to oxygen deprivation stress. [Clin Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISTransfection of episomal plasmid vectors into human pancreatic tissue efficiently generated induced expandable tissue-specific progenitor (iTP) cells expressing genetic markers of endoderm and pancreatic progenitors. [Mol Ther Methods Clin Dev] Abstract | Full Article Researchers produced recombinant regenerating protein 2 (rReg2) and proved its protective effect against streptozocin-induced diabetes in BALB/c mice. Direct rReg2 pretreatment preserved islet β-cell mass and improved glycemia, bodyweight and serum insulin content. [Diabetes Obes Metab] Abstract Scientists attempted to expand pancreatic progenitors (PPs) derived from four human iPSC lines in three-dimensional culture using a chemically defined medium and examined the potential of the derived PPs to differentiate into β-like cells. [Sci Rep] Full Article Five new examples (two flavones and three isoflavones) strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets and one isoflavone was a potent inhibitor of α-glucosidase. [Org Biomol Chem] Abstract TRPV2 Channels Mediate Insulin Secretion Induced by Cell Swelling in Mouse Pancreatic β-Cells Cytosolic Ca2+ concentration elevation was partially inhibited by ruthenium red, a blocker of several Ca2+-permeable channels including transient receptor potential vanilloid receptors, and by nicardipine, but not by the depletion of intracellular Ca2+ stores with thapsigargin and caffeine. [Am J Physiol Cell Physiol] Abstract PANCREATIC CANCERTHZ1 Reveals CDK7-Dependent Transcriptional Addictions in Pancreatic Cancer Multiple long-established and patient-derived pancreatic ductal adenocarcinoma (PDAC) cell lines were used to validate the efficacy of THZ1 in vitro. In addition, patient-derived xenograft models and animal models of PDAC were utilized for examining THZ1 efficacy in vivo. [Oncogene] Abstract Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic cancers had intrinsic resistance to CDK4/6 inhibition that was not due to any established mechanism or published biomarker. [Oncogene] Abstract When pancreatic ductal adenocarcinoma cells were cultured on a desmoplastic matrix plus pancreatic stellate cells maintained in hypoxia, KV11.1 activity determined the organization of cortical f-actin into sparse and long filopodia, and allowed f-actin polymerization at a high speed. [Cancers] Full Article Perineural Invasion in Pancreatic Cancer: Proteomic Analysis and In Vitro Modeling The tested pancreatic ductal adenocarcinoma (PDAC) cell lines were found to be able to induce neuronal plasticity in PC12 cells in the in vitro established co-culture model. Changes in expression levels of VGF, as well as of two additional proteins previously reported to be overexpressed in perineural invasion, nestin and neuromodulin, closely recapitulated proteomic findings in PDAC tissues. [Mol Oncol] Abstract | Full Article The authors confirmed that a synergistic cytotoxic effect of sequential exposure of pancreatic cancer cells to gemcitabine (Gem) followed by cisplatin (CDDP) could be mimicked by co-delivery of CDDP-loaded nanogels and free Gem. [J Pharmacol Exp Ther] Abstract | Full Article B7-H3 Is Regulated by BRD4 and Promotes TLR4 Expression in Pancreatic Ductal Adenocarcinoma Researchers showed that B7-H3 acted as a negative prognostic biomarker in pancreatic ductal adenocarcinoma and promoted cell proliferation, invasion and metastasis in pancreatic cancer. [Int J Biochem Cell Biol] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSThe authors focus on the pathophysiology of insulin and adenosine receptors and L-arginine and adenosine membrane transporters, giving an overview of key adipokines leptin and adiponectin in the foetoplacental vasculature in gestational diabetes mellitus. [Biochim Biophys Acta Mol Basis Dis] Abstract | Graphical Abstract Animal Models for Modeling Pancreatic Cancer and Novel Drug Discovery Genetically engineered mouse models as well as syngenic and xenotransplantation models are summarized and critically discussed with respect to their value for pancreatic cancer translational research. [Expert Opin Drug Discov] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSSTEMCELL Technologies has released mTeSRâ„¢ Plus, an enhanced version of mTeSRâ„¢1, the most widely published feeder-free human pluripotent stem cell (hPSC) maintenance medium. The new medium has undergone successful beta testing with several members of the Stem Cell COREdinates group and has completed rigorous in-house validation testing. [STEMCELL Technologies Inc.] Press Release Provention Bio, Inc. announced that it has received a Notice of Allowance from the United States Patent and Trademark Office for its patent application titled, “Multi-CBV Vaccine for Preventing or Treating Type 1 Diabetes.” [Provention Bio, Inc.] Press Release The Lustgarten Foundation announced the opening of its fourth dedicated pancreatic cancer research laboratory at Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore, Maryland. [Lustgarten Foundation] Press Release | |
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POLICY NEWSScientists Protest Plan to Weaken US Gender-Discrimination Law A controversial US government proposal to change the law that prohibits gender discrimination in education has drawn more than 89,000 public comments, including many from scientists. At issue is the future of Title IX, the 1972 statute that is the primary legal weapon for battling sexual harassment and other sexual misconduct in US academia. [Nature News] Editorial Chinese Effort to Clone Gene-Edited Monkeys Kicks Off Researchers around the world interested in unraveling the mechanisms of complex human disorders, such as Alzheimer’s disease, could soon have access to cloned monkeys with genomes that have been edited to display these conditions in China. [Nature News] Editorial
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EVENTSNEW Keystone Symposia: Integrating Metabolism and Immunity Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Pancreatic Beta-Cells (City of Hope) NEW Clinical Professor – Diabetes (University of Southern Denmark) Research Technologist – Pancreatic Cell Research (STEMCELL Technologies Inc.) Postdoctoral Fellowship – Pancreatic Cancer (Dartmouth College) Postdoctoral Fellowships – Cancer (Albert Einstein College of Medicine of Yeshiva University) Faculty Position – Diabetes (Sanford Research) Postdoctoral Fellow – Cancer Biology (SRI Biosciences) Faculty Positions – Diabetes and Metabolism (Texas Tech University) Postdoctoral Fellowship – Developmental and Cancer Biology (University of Copenhagen) Postdoctoral Research Associate – Stem Cells and Regenerative Medicine (King’s College London) Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey) Postdoctoral Position – Stem Cells and Diabetes (A*STAR) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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