Pancreatic Cell News Volume 11.18 | May 12 2020

TOP STORY

Contrast-Enhanced Ultrasound with Sub-Micron Sized Contrast Agents Detects Insulitis in Mouse Models of Type 1 Diabetes

Researchers report that sub-micron sized ‘nanobubble’ ultrasound contrast agents could be used to measure increased islet microvasculature permeability and indicated asymptomatic type 1 diabetes. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

A Method for the Generation of Human Stem Cell-Derived Alpha Cells

Scientists report on the generation of stem cell-derived human pancreatic alpha cells from pluripotent stem cells via a transient pre-alpha cell intermediate. [Nat Commun] Full Article

Receptor-Targeted Photodynamic Therapy of Glucagon-Like Peptide 1 Receptor Positive Lesions

The authors describe a novel method for therapy of hyperinsulinemic hyperglycemia, highly selectively killing beta cells by targeted photodynamic therapy with exendin-4-IRDye700DX, targeting the glucagon-like peptide 1 receptor. [J Nucl Med] Abstract | Full Article

Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity and Ameliorates Type 1 Diabetes

Researchers report that dextran sulfate, but not dextran, protected human β-cells against cytokine-mediated cytotoxicity in vitro. Dextran sulfate also protected mitochondrial function and glucose-stimulated insulin secretion. [Diabetes] Abstract

Serine Administration as a Novel Prophylactic Approach to Reduce the Severity of Acute Pancreatitis during Diabetes in Mice

Scientists elucidated the molecular mechanisms underlying the lipotoxicity exerted by 1-deoxysphingolipids towards rodent pancreatic acinar cells in vitro. [Diabetologia] Abstract

Glucose-Dependent Partitioning of Arginine to the Urea Cycle Protects β-Cells from Inflammation

The authors showed the contribution of glucose metabolism to inflammation-induced changes in the survival of pancreatic islet β-cells. [Nat Metab] Abstract

PANCREATIC CANCER

ZBED2 Is an Antagonist of Interferon Regulatory Factor 1 and Modifies Cell Identity in Pancreatic Cancer

ZBED2 attenuated the transcriptional output and growth arrest phenotypes downstream of IFN signaling in multiple pancreatic ductal adenocarcinoma cell line models. [Proc Natl Acad Sci USA] Abstract

Phage Display Selection, Identification, and Characterization of Novel Pancreatic Cancer Targeting Peptides

Peptides that targeted pancreatic cancer cells were selected using phage display technology using a 15-mer fUSE5 library. Phage were pre-cleared against immortalized pancreatic cells, followed by selections against pancreatic cancer cells. [Biomolecules] Full Article

Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation

Three different human pancreatic cancer cell lines were compared to normal pancreatic epithelial cells revealing distinct differences in protein cargo between cancer and normal vesicles. [Sci Rep] Full Article

Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity

The authors investigated the protective effect of cyanidin against methylglyoxal-induced oxidative stress and apoptosis in rat INS-1 pancreatic β-cells. [Nutrients] Full Article

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Pancreatic Cancer Stroma: An Update on Therapeutic Targeting Strategies

The authors discuss their current understanding of the three principal constituents of pancreatic ductal adenocarcinoma stroma, their effect on the prevalent immune landscape and promising therapeutic targets within this compartment. [Nat Rev Gastroenterol Hepatol] Abstract

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NANOBIOTIX Announces First Phase I Trial with NBTXR3 in Pancreatic Cancer Is Safe to Proceed per US FDA

Nanobiotix announced that the protocol for the first trial from its clinical collaboration with The University of Texas MD Anderson Cancer Center has been designated as “safe to proceed” by the FDA. [Nanobiotix (BusinessWire, Inc.)] Press Release

PharmaCyte Biotech Receives Medical Devices Registration and Submits Pre-EUA Application to the FDA for COVID-19 Diagnostic Kit

PharmaCyte Biotech, Inc. announced that it has received Medical Devices Establishment Registration with the FDA’s Center for Devices and Radiological Health. [PharmaCyte Biotech, Inc.] Press Release

Secretive Jasons to Offer Advice on How to Reopen Academic Labs Shut by Pandemic

A group of prominent academic scientists that has been advising the US government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security-the impact of COVID-19 on academic research. And this time it’s personal. [ScienceInsider] Editorial

How Swamped Preprint Servers Are Blocking Bad Coronavirus Research

Repositories are rapidly disseminating crucial pandemic science – and they’re screening more closely to guard against poor-quality work. [Nature News] Editorial

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NEW Postdoctoral Position – Diabetic Endothelial Cell Remodeling (Aarhus University)

Postdoctoral Fellowship – Pancreatic Progenitor Research (University of Copenhagen)

PhD/MD/MCh Medical Traineeship – Pancreatic Cancer (University College Dublin)

PhD Studentship – Cancer Biology Research (Danish Cancer Society Research Center)

PhD Research Scientist – Beta Cells in Diet-Induced Diabetes (Medical University of Vienna)

Laboratory Manager – Diabetes (Helmholtz Zentrum München)

Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech)

Postdoctoral Research Position – Cancer Therapeutics (NIH National Cancer Institute)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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