Pancreatic Cell News Volume 11.21 | Jun 2 2020

TOP STORY

Electrogenetic Cellular Insulin Release for Real-Time Glycemic Control in Type 1 Diabetic Mice

Focusing on type 1 diabetes, scientists engineered electrosensitive human β cells (Electroβ cells). Wireless electrical stimulation of Electroβ cells inside a custom-built bioelectronic device provided real-time control of vesicular insulin release. [Science] Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Pre-Clinical Evaluation of TYK2 Inhibitors for Human Beta Cell Protection in Type 1 Diabetes

Two TYK2 inhibitors provided by Nimbus Lakshmi Inc, were tested in human insulin-producing EndoC-βH1 cells and human islets to evaluate their effect on interferon-α signaling and beta cell function. [Diabetes Obes Metab] Abstract

Pro-Inflammatory Cytokine Interleukin 1β Disrupts β Cell Circadian Clock Function and Regulation of Insulin Secretion

Scientists provide evidence that the key diabetogenic cytokine IL-1β disrupted functionality of the β cell circadian clock and impaired circadian regulation of glucose-stimulated insulin secretion. [Endocrinology] Abstract

Role of DNA-LL37 Complexes in the Activation of Plasmacytoid Dendritic Cells and Monocytes in Subjects with Type 1 Diabetes

Following in vitro stimulation with DNA-LL37 complexes, type 1 diabetes group demonstrated higher frequency and mean fluorescence intensity of plasmacytoid dendritic cells expressing IFN-α. [Sci Rep] Full Article

Nicotine Triggers Islet β Cell Senescence to Facilitate the Progression of Type 2 Diabetes

Investigators demonstrated that nicotine induced premature senescence of pancreatic β cells in vitro and in vivo. [Toxicology] Abstract

PANCREATIC CANCER

ISG15 and ISGylation Is Required for Pancreatic Cancer Stem Cell Mitophagy and Metabolic Plasticity

The authors demonstrated that pancreatic cancer stem cells increased expression of interferon-stimulated gene 15 (ISG15) and protein ISGylation, which were essential for maintaining their metabolic plasticity. [Nat Commun] Full Article

Oncolytic Adenovirus Expressing ST13 Increases Antitumor Effect of TRAIL against Pancreatic Ductal Adenocarcinoma

CD55-ST13-TRAIL had a synergic cell-killing effect compared with CD55-ST13 alone or CD55-TRAIL alone, and the inhibition of pancreatic ductal adenocarcinoma (PDAC) cell metastasis and promotion of apoptosis by triggering EMT and apoptotic pathways in PDAC cells. [Hum Gene Ther] Abstract

Role of Exosomal MicroRNA-125b-5p in Conferring the Metastatic Phenotype among Pancreatic Cancer Cells with Different Potential of Metastasis

Pancreatic cancer cells transfected with miR-125b-5p mimic and inhibitor were used to explore the effect of miR-125b-5p on migration, invasion and epithelial-to-mesenchymal transition. [Life Sci] Abstract

Acetylation Promotes BCAT2 Degradation to Suppress BCAA Catabolism and Pancreatic Cancer Growth

The lysine 44 mutant promoted branched-chain amino acid catabolism, cell proliferation, and pancreatic tumor growth. [Signal Transduct Target Ther] Full Article

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Pancreatic Cancer Treatment: Better, but a Long Way to Go

The authors highlight the historical perspectives of pancreatic cancer treatment and outline the areas of future advancement that will assist progression towards better outcomes. [Surg Today] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Amid COVID-19 Pandemic, DreaMed Diabetes Announces Implementation of Its Advisor Pro Software at Top-Rated US Children’s Hospital

DreaMed Diabetes Ltd. announced a cooperation with Texas Children’s Hospital by integrating its Advisor Pro software to help diabetes care in children and incorporate a simple remote treatment option. [DreaMed Diabetes Ltd. (BusinessWire, Inc.)] Press Release

Universities Will Never Be the Same after the Coronavirus Crisis

The coronavirus crisis is forcing universities to confront long-standing challenges in higher education, such as skyrocketing tuition costs and perceptions of elitism — and some of the resulting changes could be permanent. [Nature News] Editorial

US Looks to Block Chinese Grad Students’ and Researchers’ Visas

Administration officials and lawmakers say the move is to shore up national security threats, but university professors argue such cancellations represent targeted discrimination. [The Scientist] Editorial

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NEW PhD Student – Pancreatic Cancer (University College Dublin)

Postdoctoral Scientist Position – Drug Vulnerabilities of Pancreatic Cancer (Klinikum rechts der Isar der Technischen Universität München)

Postdoctoral Research Associate – Tumor Biology (University of Würzburg)

Postdoctoral Associate – Pancreatic Disease Research (University of Miami Health System)

Postdoctoral Fellow – Pancreas and Islet Biology Research (Vanderbilt University Medical Center)

Postdoctoral Position – Diabetic Endothelial Cell Remodeling (Aarhus University)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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