 | | Vol. 11.27 – 21 July, 2020 |
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| The authors performed single‐cell transcriptomic analyses using combinational barcoding exclusively on epithelial cells from six different classical pancreatic ductal adenocarcinoma patients obtained by Endoscopic Ultrasound with Fine Needle Aspiration.
[FASEB Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers present a simple approach for islet preconditioning that uses the antibiotic mitomycin C, which has antitumor activity, to reduce islet immunogenicity and prevent proinflammatory events in an intraportal islet transplantation model.
[Scientific Reports] |
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| Investigators found that tectorigenin could suppress induced apoptosis and improved the viability of β-cells under glucotoxicity and lipotoxicity by activation of ERK and reduction of reactive oxygen species and endoplasmic reticulum stress.
[Journal of Biological Chemistry] |
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| Tissue microarray blocks were constructed and stained immunohistochemically using CD73 antibody. Staining intensity and numbers of stained tumor cells, inflammatory cells, stroma, and blood vessels were assessed.
[Virchows Archiv] |
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| Scientists identified effective combination chemotherapy for pancreatic cancer using pancreatic cancer surgical specimens in the histoculture drug response assay based on 3D culture of tumor fragments, which maintained nature tumor histology in vitro.
[Scientific Reports] |
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| Inhibition of ubiquitin activating enzyme 1 (UAE1) activity in response to TAK-243 led to an accumulation of misfolded proteins within the endoplasmic reticulum (ER), thereby aggravating ER stress, leading to DNA damage and arrest of cells in the G2/M phase of the cell cycle.
[Translational Oncology] |
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| Scientists report that USP22 promoted the growth of pancreatic ductal adenocarcinoma cells by promoting the expression of dual-specificity tyrosine regulated kinase 1A.
[Gene] |
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| The expression of PD-L1 in tumors has been described in many histological types of cancer: melanoma, lung cancer, breast and ovarian, pancreatic and esophagus adenocarcinoma, kidney tumors and bladder cancers as well as in hematopoietic malignancies.
[Experimental and Molecular Pathology] |
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| CalciMedica and EpiPharma announced that they have entered into a collaboration agreement to use EpiPharma’s state-of-the-art pre-Clinical Drug Testing and Diagnostics Laboratory Platform to accelerate the discovery and development of CalciMedica’s CRAC channel inhibitor novel drug pipeline.
[CalciMedica] |
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| Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[ScienceInsider] |
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| Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider] |
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| Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News] |
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| October 20 – October 21
Virtual |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Lund University – Lund, Sweden |
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| | Stanford Institute for Stem Cell Biology and Regenerative Medicine – Stanford, California, United States |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| | Cornell University – New York City, New York, United States |
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