 | | Vol. 13.32 – 23 August, 2022 |
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| LINC00623 was shown to promote the tumorigenicity and migratory capacity of PDAC cells in vitro and in vivo.
[Journal of Hematology & Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that although proteasomal inhibition immediately downregulated new proinsulin biosynthesis, it nevertheless acutely increased beta cell proinsulin levels in pancreatic beta cell lines, rodent pancreatic islets, and human islets.
[Journal of Biological Chemistry] |
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| Researchers reported that incubation of INS-1832/13 cells and rat islets with high glucose significantly increased the expression of Alpha4.
[Molecular and Cellular Endocrinology] |
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| Investigators summarize the different endocrine and non-endocrine cell populations that have been described to emerge throughout β cell differentiation and after transplantation.
[Developmental Cell] |
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| Scientists demonstrated that a reduction in SF3B1 levels via monoallelic deletion of Sf3b1 impeded tumor formation and progression via impaired hypoxia-inducible factor (HIF) signaling in a mouse model for pancreatic cancer.
[Cell Reports] |
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| Using CRISPR/Cas9 activation library screen, the authors discovered that MTA3 mediated the gemcitabine (GEM) resistance of PDAC and thus might be a potential therapeutic target for combination chemotherapy.
[Cancer Letters] |
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| Using functional experiments and mice models, scientists discovered that LINC00941 overexpression promoted pancreatic cancer (PC) proliferation and metastasis.
[Cell Death & Disease] |
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| Co-culture of pancreatic cancer cells with M2 macrophage-derived extracellular vesicles enriched with miR-222-3p suppressed the sensitivity to gemcitabine, accompanied by diminished apoptosis and promoted proliferation.
[Cell Biology and Toxicology] |
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| Scientists reported that epithelium-specific E-twenty six factor 3 (ESE3) expression increased in pancreatic stellate cells (PSCs) in PDAC tissues compared with those in normal PSCs.
[British Journal of Cancer] |
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| Using CCK-8, colony formation, RTCA test, wound healing, as well as transwell test, researchers demonstrated that the overexpression of dermokine-α (DMKN-α) enhanced the proliferation, migration, invasion, and EMT of pancreatic cancer cells.
[Cellular Signalling] |
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| Investigators evaluate the effect of tomentosin on the migration and invasion of pancreatic cancer cells.
[Toxicology in Vitro] |
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| The authors discuss relevant and current information on epidemiology, pathology, diagnosis, clinical presentation, treatment and ongoing clinical trials of these two entities, in order to illustrate the two sides of the moon.
[Medical Oncology] |
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| The researchers from QIMR Berghofer, Griffith University and the Garvan Institute of Medical Research will be among the first in the world to use spatial transcriptomics technology to study how cancer cells invade nerves in the pancreas and interact with immune cells, in a bid to better understand how the cancer spreads and causes pain.
[ABC NEWS] |
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| The Pancreatic Cancer Action Network awarded $10.5 million in new research grants nationally, including $250,000 in a Career Development Award to Dr. Aaron Hobbs at MUSC for his work looking at a peculiar mutation in some pancreatic tumors that could become a biomarker and a potential target for therapy, a first for South Carolina.
[The Post and Courier] |
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| October 3 – 4, 2022
San Diego, California, United States |
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| | The University Health Network – Toronto, Ontario, Canada |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | Northwestern University – Chicago, Illinois, United States |
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