 | | Vol. 11.33 – 1 September, 2020 |
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| Investigators showed in gut epithelial cells, that galectin-9 was enriched in lysosomes and predominantly bound to lysosome-associated membrane protein 2 (Lamp2) in a Asn(N)-glycan dependent manner.
[Nature Communications] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Using genetic lineage tracing, transcriptome, and functional studies, researchers identified mesenchymal populations with different roles during pancreatic development.
[Developmental Cell] |
| | The authors provided a comprehensive resource for understanding human islet cell maturation and provided important insights into maturation of human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) and other SC-islet cell types to enable future differentiation strategy improvements.
[Cell Reports] |
| | Scientists proposed a simple and elegant model using a cytokine cocktail of TNF-α, IFN-γ and IL-1β, the major cytokines responsible for apoptosis in the Min6 pancreatic beta cell line.
[Journal of Pharmacological and Toxicological Methods] |
| | Researchers showed that CNOT3, a CCR4–NOT deadenylase complex subunit, was dysregulated in islets in diabetic db/db mice, and that it was essential for murine β cell maturation and identity.
[Communications Biology] |
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| Compromised gustatory sensing, achieved by Gnat3 ablation, enhanced the CXCL1/2 – CXCR2 axis to alter the myeloid-derived suppressor cell population and promoted the progression of metastatic pancreatic ductal adenocarcinoma.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Scientists observed that hypoxic exosomes derived from pancreatic cancer cells promoted cell migration and tube formation of human umbilical vein endothelial cells.
[Molecular Therapy-Nucleic Acids] |
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| Investigators found that Methyl-CpG-binding protein 2 was upregulated in pancreatic cancer tissues, enhanced migration, invasion, and proliferation in pancreatic cancer cells, and promoted tumorigenesis.
[Oncogenesis] |
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| The authors demonstrated that circSFMBT1 and PAK1 were up-regulated in pancreatic cancer tissues and cells, while miR-330-5p was down-regulated. circSFMBT1 directly bound miR-330-5p and inhibited its expression.
[Cancer Gene Therapy] |
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| Pancreatic ductal adenocarcinoma is one of the most lethal solid malignancies in the world due to its insensitivity to current therapies and its propensity to metastases from the primary tumor mass. This is largely attributed to its complex microenvironment composed of unique stromal cell populations and extracellular matrix.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| The authors present approaches to generate islet cell organoids and discuss how these strategies can be applied to the generation of a bioartificial pancreas for the treatment of type 1 diabetes.
[Transplant International] |
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| AGC Biologics has achieved the on-schedule completion of a drug substance Process Performance Qualification campaign, focused on teplizumab for partner Provention Bio, Inc. Teplizumab, Provention Bio’s lead drug candidate, is an anti-CD3 monoclonal antibody being developed for the delay or prevention of type 1 diabetes.
[AGC Biologics (PR Newswire)] |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | NYU Langone Health – New York, New York, United States |
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| | City of Hope – Monrovia, California, United States |
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| | New York University School of Medicine – New York, New York, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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