Pancreatic Cell News Volume 11.38 | Oct 6 2020

May 12, 2022

2020-10-06 | PACN 11.38

Pancreatic Cell News by STEMCELL Technologies

Vol. 11.38 – 6 October, 2020

TOP STORY

Genetic
Variant Effects on Gene Expression in Human Pancreatic Islets and Their Implications for T2D

The authors explored the relationship between genetic variants influencing predisposition to type 2 diabetes and related glycemic traits, and human pancreatic islet transcription using data from 420 donors.
[Nature Communications]

Full Article

Virtual Conference Exhibition: Organoids

PUBLICATIONSRanked by the impact factor of the journal

DIABETES & PANCREATITIS

Topologically
Selective Islet Vulnerability and Self-Sustained Downregulation of Markers for β-Cell Maturity in Streptozotocin-Induced Diabetes

Scientists showed that hyperglycemic Streptozotocin-treated mice still harbor a large pool of remaining β-cells but displayed pancreas-wide downregulation of glucose transporter type 2. Islet gene expression studies confirmed this downregulation and revealed impaired β-cell maturity.
[Communications Biology]

Full Article

PANCREATIC CANCER

Pancreatic
Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis

Investigators found that pancreatic ductal adenocarcinomas overexpressed the myelin regulatory factor, an ER membrane-associated transcription factor released by self-cleavage.
[Developmental Cell]

Full Article Graphical Abstract

Single-Cell
Transcriptome Analysis of Tumor and Stromal Compartments of Pancreatic Ductal Adenocarcinoma Primary Tumors and Metastatic Lesions

Scientists employed a single-cell RNA sequencing technology to profile the transcriptomes of individual cells from dissociated primary tumors or metastatic biopsies obtained from patients with pancreatic ductal adenocarcinoma.
[Genome Medicine]

Full Article

Cdc6
Disruption Leads to Centrosome Abnormalities and Chromosome Instability in Pancreatic Cancer Cells

Cell division cycle 6 (Cdc6)-depleted pancreatic cancer cells significantly inhibited cell proliferation and colony formation, delayed G2/M cell cycle progression, and increased expression of p-histone H3 and cyclin A2 levels.
[Scientific Reports]

Full Article

Diltiazem
Potentiates the Cytotoxicity of Gemcitabine and 5-Fluorouracil in PANC-1 Human Pancreatic Cancer Cells through Inhibition of P-Glycoprotein

The cytotoxic effect of diltiazem, gemcitabine, and 5-fluorouracil in single and combined forms against PANC-1 and AsPC-1 cells were assayed by MTT. Flow cytometric analysis was used for the determination of cell cycle, apoptosis, and stemness markers in pancreatic cancer cells.
[Life Sciences]

Abstract

Tumor-Associated Macrophages Derived from Cancer Stem Cells

This study displayed histological and immunohistochemical analyses of a malignant tumor model developed from cancer stem cells converted from human iPSCs in a cancer microenvironment prepared from the conditioned medium of a pancreatic cancer cell line.
[Acta Histochemica]

Full Article

Download an e-book covering the evolution of organoids, from their development to updated applications and future outlooks.

REVIEWS

Molecular
Alterations and Targeted Therapy in Pancreatic Ductal Adenocarcinoma

The authors focus on recent pre-clinical and clinical advances in therapies targeting aberrant genes and pathways and predict the future trend of precision oncology for pancreatic ductal adenocarcinoma.
[Journal of Hematology & Oncology]

Full Article

INDUSTRY AND POLICY NEWS

Zucara
Therapeutics Doses First Subject in Phase I Trial of ZT-01

Zucara Therapeutics, Inc. announced that it has dosed the first subject in its Phase I trial of ZT-01. The study results will help define ZT-01’s safety profile and establish doses to be used in an additional planned Phase I study to show the effect on glucagon during hypoglycemia in T1D patients.
[Zucara Therapeutics, Inc.]

FEATURED EVENT

Genetic
Variant Effects on Gene Expression in Human Pancreatic Islets and Their Implications for T2D

Topologically
Selective Islet Vulnerability and Self-Sustained Downregulation of Markers for β-Cell Maturity in Streptozotocin-Induced Diabetes

Pancreatic
Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis

Single-Cell
Transcriptome Analysis of Tumor and Stromal Compartments of Pancreatic Ductal Adenocarcinoma Primary Tumors and Metastatic Lesions

Cdc6
Disruption Leads to Centrosome Abnormalities and Chromosome Instability in Pancreatic Cancer Cells

Diltiazem
Potentiates the Cytotoxicity of Gemcitabine and 5-Fluorouracil in PANC-1 Human Pancreatic Cancer Cells through Inhibition of P-Glycoprotein

Tumor-Associated Macrophages Derived from Cancer Stem Cells

Molecular
Alterations and Targeted Therapy in Pancreatic Ductal Adenocarcinoma

Zucara
Therapeutics Doses First Subject in Phase I Trial of ZT-01

The
Evolving Tumor Microenvironment In Cancer Progression: Mechanisms And Emerging Therapeutic Opportunities

> See All Events

Postdoctoral Fellow – Diagnosis and Prognosis of Pancreatic Cancer

Research Fellow – Pancreatic and Liver Cancers

Postdoctoral Position – Gestational Diabetes

Assistant
Research Professor – Molecular Diagnostics and Experimental Therapeutics

Postdoctoral
Fellow – Pancreatic Cancer

> See All Jobs