 | | Vol. 11.39 – 10 October, 2023 |
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| In a phase II, placebo-controlled, randomized, parallel group, double-blind trial, 96 children and adolescents with new-onset T1D received antiviral treatment with pleconaril and ribavirin or placebo for six months, with the aim of preserving β cell function.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In a fecal microbiota transplantation mouse model, the colonization of gut microbiota from hypertriglyceridemic pancreatitis patients recruited neutrophils and increased neutrophil extracellular traps formation that exacerbated pancreatic injury and systemic inflammation.
[Nature Communications] |
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| To understand the contribution of CTCF-mediated chromatin organization to cell lineage commitment, investigators analyzed 3D chromatin architecture during the differentiation of human embryonic stem cells into pancreatic islet organoids.
[Nature Communications] |
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| Adults and adolescents with type 1 diabetes diagnosed within 150 days were enrolled, with documented evidence of at least one autoantibody and a stimulated peak C-peptide level >0.2 nmol/l.
[Diabetologia] |
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| A new method was developed to permit the long-term culture of islets. Human islets were embedded in polysaccharide 3D-hydrogel in cell culture inserts or gas-permeable chambers with serum-free CMRL 1066 Supplemented media for up to eight weeks.
[American Journal Of Transplantation] |
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| When crossed to CAG-LSL-MycT58A mice, Msi2-CreERT2 mice developed multiple pancreatic cancer subtypes: ductal, acinar, adenosquamous, and rare anaplastic tumors.
[Cancer Cell] |
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| Genetic extinction or pharmacological inhibition of KRAS* resulted in up-regulation of ERBB2 and ERBB3 expression in human and murine models, which prompted cancer cell utilization of cancer-associated fibroblast-derived NRG1 as a survival factor.
[Genes & Development] |
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| Researchers proposed that oncogenic dependency, rather than KRAS mutation per se, played a dominant role in the immune response to cancer, including late-stage PDAC.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists conducted single-cell RNA-seq analysis on a residual lesion from a microsatellite instability high (MSI-H) PDAC patient who received a radical operation after eight cycles of neoadjuvant treatment.
[Cancer Letters] |
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| The authors highlight contemporary areas of research, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies and immunotherapies.
[Nature Reviews Gastroenterology & Hepatology] |
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| Dr. Maddipati specializes in disorders of the pancreas and management of patients at high risk for developing pancreatic cancer. Building on optogenetic tools used for basic neurobiology, he plans to use the funding to design mouse models in which genes can be preferentially activated by exposure to light.
[UT Southwestern Medical Center] |
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| October 29 – November 3, 2023
Hinxton, England, United Kingdom |
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| | Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States |
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| | Stanford University – Stanford, California, United States |
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| | The University of Tennessee – Memphis, Tennessee, United States |
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| | Beth Israel Deaconess Medical Center & Harvard Medical School – Boston, Massachusetts, United States |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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