 | | Vol. 11.40 – 20 October, 2020 |
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| Researchers FACS-purified epithelial cells from human pancreatic ductal adenocarcinoma and normal pancreas and derived their genome-wide transcriptome and DNA methylome landscapes.
[Cancer Discovery] |
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| Scientists found a consistent, abnormal methylation pattern in insulinomas. They found that abnormal insulin (INS) promoter methylation and altered transcription factor expression created alternative drivers of INS expression, replacing canonical PDX1-driven beta cell specification with a pathological, looping, distal enhancer-based form of transcriptional regulation.
[Nature Communications] |
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| Researchers present an automated, high-throughput, microfluidic 3D organoid culture and analysis system to facilitate preclinical research and personalized therapies. They validated the system by performing individual, combinatorial, and sequential drug screens on human-derived pancreatic tumor organoids.
[Nature Communications] |
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| miR-124 or EZH2 was overexpressed in AsPC-1 and PANC1 cells. Then, the effects on cell viability, apoptosis, invasion, migration and epithelial mesenchymal transition were evaluated. The roles of miR-124 on the expression and function of EZH2 in pancreatic tumors were determined by dual luciferase reporter assay.
[Aging] |
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| Several in vitro and in vivo mechanisms involved in PDAC metastases were investigated following treatment with P-AscH−. Serum from PDAC patients in clinical trials with P-AscH− were tested for the presence and quantity of circulating tumor cell-derived nucleases.
[Scientific Reports] |
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| Investigators showed interlukine-17 receptor B (IL-17RB) expression was positively correlated with mucin 1 (MUC1) and MUC4 expression in pancreatic cancer cells and tumor tissue.
[Scientific Reports] |
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| In CFPAC-I and HPAF-II pancreatic cancer cell lines, the combined in vitro effect of tumor treating fields and radiotherapy was evaluated by measuring cell counts, markers of apoptosis, and clonogenic cell survival.
[International Journal of Radiation Biology] |
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| Researchers showed that SPARC enhanced the promoting effect of Muscarinic receptor agonist oxotremorine-M on insulin secretion in cultured mouse islets. Overexpression of SPARC down-regulated RGS4, a negative regulator of β-cell M3 muscarinic receptors.
[Scientific Reports] |
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| The authors focus on three types of well-established non-coding RNAs — miRNAs, long non-coding RNAs, and circular RNAs— and discuss their potential as diagnostic, prognostic and predictive biomarkers in pancreatic ductal adenocarcinoma.
[Seminars in Cancer Biology] |
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| Scientists present the AMP-activated protein kinase (AMPK) role in eukaryotic cells and focus on the relationship between AMPK activity and the regulation of base excision repair system through its main component—8-oxoguanine glycosylase
[Molecular Biology Reports] |
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| Apexigen, Inc. announced that the US FDA has granted orphan drug designation status to APX005M for the treatment of esophageal and gastroesophageal junction cancer and for the treatment of pancreatic cancer.
[Apexigen Inc.] |
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| The Pancreatic Cancer Action Network announced the launch of Precision PromiseSM, the first of its kind adaptive clinical trial platform for pancreatic cancer patients.
[Pancreatic Cancer Action Network (PR Newswire, LLC)] |
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| January 25 – January 28, 2021
Virtual |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Roswell Park Cancer Center – Buffalo, New York, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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| | The Mayo Clinic – Jacksonville, Florida, United States |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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