 | | Vol. 11.41 – 27 October, 2020 |
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| Investigators describe a 2D in vitro system for long-term enrichment of pancreatic cancer stem cells (CSCs) that was amenable to biological and CSC-specific studies.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers performed an in vivo CRISPR screen in an orthotopic patient-derived xenograft model to identify gene targets whose inhibition created synergistic tumor growth inhibition with gemcitabine, a first- or second-line chemotherapeutic agent for pancreatic ductal adenocarcinoma treatment.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists investigated the role of distinct subtypes of pancreatic cancer stem cells and their metabolomic signatures in organ-specific metastatic colonization.
[Oncogene] |
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| Investigators observed that Lin28B was up‐regulated in pancreatic cancer, contributing to cellular migration and proliferation. Nuclear Lin28B upregulated TET3 mRNA and protein levels by blocking the production of mature let‐7i.
[Molecular Oncology] |
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| NLRP3 inflammasome-related gene (Nlrp3 and Il1b) expression was upregulated in islets stimulated with proinflammatory cytokines and suppressed when incubated with MCC950.
[Scientific Reports] |
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| The authors demonstrate a method that without prior immunohistochemical labeling, provides insight into the 3D microenvironment and spread of PDAC and premalignant cysts in intact surgical biopsies.
[Scientific Reports] |
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| Investigators researched long‐term saturated fatty acid overexposure that can induce differentiation of pancreatic duct cells into adipocytes and also into β‐cells.
[Journal of Cellular Physiology] |
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| Researchers analyzed the most effective autophagic-inducing conditions in PDAC cells and the effect exerted under these conditions in association with hypoxia on the galectin-3 expression.
[Microscopy and Microanalysis] |
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| Scientists systematically compared zinc and insulin contents in the permanent INS-1E and BRIN-BD11 β-cells and in the native rat pancreatic islets by flow cytometry, confocal microscopy, immunoblotting, specific messenger RNA and total insulin analysis.
[Open Biology] |
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| The authors summarize published studies pointing to common potential cells of origin and speculate about how the distinct paths of differentiation are determined by the genomic patterns of each disease.
[Experimental Hematology & Oncology] |
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| The Stem Cell Network announced today $4.3 million in funding to support stem cell and regenerative medicine research projects that will help to deliver improved health for Canadians and will contribute to national economic recovery. Funded projects include stem cell-based research into new therapeutics for type-1 diabetes, cancer, cystic fibrosis, brain and heart conditions.
[Stem Cell Network] |
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| Congratulations to Dr. Cherie Stabler, professor in the J. Crayton Pruitt Family Department of Biomedical Engineering, for receiving a $1.7 million RO1 grant from the NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for her project, “Engineering Immunomodulatory Nanoscale Coatings for Protecting Islet Transplants.”
[The University of Florida] |
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| March 17 – March 19, 2021
Virtual |
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| | San Diego Biomedical Research Institute – La Jolla, California, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Roswell Park Cancer Center – Buffalo, New York, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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