 | | Vol. 11.43 – 24 November, 2020 |
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| Researchers showed that persistent membrane depolarization of β cells due to genetic or pharmacological inhibition of the KATP channel led to a switch from Gs to Gq in a major amplifying pathway of insulin secretion.
[Journal of Clinical Investigation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators validated the Disque Platform against standard 2D and 3D cultures and interrogated zinc-activated prodrugs, which released their cargo upon zinc chelation- so preferentially in β cells.
[Science Advances] |
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| Single cell RT-PCR was used to confirm that glucokinase was the main glucose-phosphorylating enzyme expressed in rat pancreatic alpha cells.
[Scientific Reports] |
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| Mechanistically, researchers demonstrated that the stimulated by retinoic acid 6 (STRA6), RBP4’s only known specific membrane receptor, was expressed in β cells and mediated the inhibitory effect of RBP4 on insulin synthesis via JAK2/STAT1/ISL-1 pathway.
[Diabetes] |
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| Scientists showed that KP372-1 sensitized NAD(P)H:quinone oxidoreductase 1-expressing pancreatic cancer cells and spared immortalized normal pancreatic duct cells, hTERT-HPNE.
[Scientific Reports] |
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| Silencing HNF1α reduced the proliferative, migratory, invasive and colony forming capabilities of pancreatic cancer cells.
[Scientific Reports] |
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| Using several human and mouse models of PDACs, the authors demonstrated rapid acquisition of tumor resistance in response to targeting KRAS or MEK, associated with integrin-linked kinase-mediated increased phosphorylation of the mTORC2 component Rictor, and AKT.
[Cell Reports Medicine] |
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| Scientists treated pancreatic ductal adenocarcinoma cells with phenformin in combination with standard chemotherapy, showing that this treatment was synergistic specifically in high oxidative phosphorylation cells.
[Cell Reports Medicine] |
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| Prolonged hyperglycemia is toxic to pancreatic β cells, generating excessive reactive oxygen species, defective glucose-stimulated insulin secretion, decreased insulin production, and eventually β cell death and diabetes.
[Trends in Endocrinology and Metabolism] |
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| The authors describe recent findings on those coregulators with direct roles in maintaining islet β-cell health and identity and discuss how disruption of coregulator activity is associated with diabetes pathogenesis.
[Endocrinology] |
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| Oramed Pharmaceuticals, Inc. announced it has screened the first patients in its global Phase III trials of its oral insulin capsule ORMD-0801 for the treatment of type 2 diabetes. The patients were screened at US sites participating in Oramed’s ORA-D-013-1 trial, one of two Phase III trials being conducted in accordance with FDA approved protocols.
[Oramed Pharmaceuticals, Inc.] |
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| Chiasma, Inc. announced positive top-line data from its global Phase III MPOWERED™ non-inferiority clinical trial comparing MYCAPSSA® to long-acting injectable somatostatin analogs for maintenance of biochemical response in patients with acromegaly.
[Chiasma, Inc.] |
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| October 4 – October 8, 2021
Singapore, Singapore |
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| | Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | San Diego Biomedical Research Institute – La Jolla, California, United States |
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| | Stanford University – Stanford, California, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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