Pancreatic Cell News Volume 12.1 | Mar 16 2021

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    2021-03-16 | PACN 12.1


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.1 – 16 March, 2021
    TOP STORY

    Sequential Progenitor States Mark the Generation of Pancreatic Endocrine Lineages in Mice and Humans

    Researchers generated novel mouse lines and combined them with various genetic tools to enrich all types of hormone+ cells for well-based deep single-cell RNA sequencing (scRNA-seq), and gene coexpression networks were extracted from the generated data for the optimization of high-throughput droplet-based scRNA-seq analyses.
    [Cell Research]

    Abstract

    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    PUBLICATIONSRanked by the impact factor of the journal

    Neddylation Pathway Alleviates Chronic Pancreatitis by Reducing HIF1α-CCL5-Dependent Macrophage Infiltration

    Scientists demonstrated that global inactivation of the neddylation pathway by MLN4924 significantly exacerbated chronic pancreatitis. The increased M2 macrophage infiltration, mediated by the upregulated chemokine ligand 5 (CCL5), was responsible for the enhanced pancreatitis-promoting activity of MLN4924.
    [Cell Death & Disease]

    Full Article

    Pre-Existing Beta Cells but Not Progenitors Contribute to New Beta Cells in the Adult Pancreas

    The authors indicated that pancreatic endocrine and exocrine progenitor cells did not contribute to the new beta-cell formation in the adult mouse pancreas under physiological conditions.
    [Nature Metabolism]

    Abstract

    Critical Parameters to Improve Pancreatic Cancer Treatment Using Magnetic Hyperthermia: Field Conditions, Immune Response, and Particle Biodistribution

    Several alternating magnetic field conditions were evaluated using 3D cell culture models loaded with magnetic nanoparticles to determine which conditions were producing a strong effect on the cell viability.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer

    Investigators proposed long-circulating, pH-sensitive nanoparticles composed solely of cellular membrane-disruptive molecules as a new approach for treating pancreatic cancer.
    [ACS Applied Materials & Interfaces]

    Abstract

    Roundabout Homolog 1 Inhibits Proliferation via the YY1-ROBO1-CCNA2-CDK2 Axis in Human Pancreatic Cancer

    Scientists explored whether ROBO1 had effects on the proliferation of pancreatic cancer and its specific mechanism.
    [Oncogene]

    Abstract

    Natural Product Trienomycin A Is a STAT3 Pathway Inhibitor That Exhibits Potent In Vitro and In Vivo Efficacy against Pancreatic Cancer

    Researchers identified the natural product Trienomycin A, an ansamycin antibiotic, as a potential inhibitor of the Signal Transducer and Activator of Transcription-3 (STAT3) pathway with potent activity against pancreatic cancer.
    [British Journal of Pharmacology]

    Abstract

    EphA2 Super-Enhancer Promotes Tumor Progression by Recruiting FOSL2 and TCF7L2 to Activate the Target Gene EphA2

    The authors explored the function and mechanism of a new super-enhancer in various tumor cells. A new super-enhancer that exists in a variety of tumors named EphA2-Super-enhancer was found using multiple databases and further identified.
    [Cell Death & Disease]

    Full Article

    Role of TGF-β in Pancreatic Ductal Adenocarcinoma Progression and PD-L1 Expression

    Scientists investigated the expression of non-SMAD-transforming growth factor-beta (TGF-β) signaling proteins in patient-derived tissues, cell lines, and an immunocompetent mouse model.
    [Cellular Oncology]

    Abstract

    SOX9 Modulates Cancer Biomarker and Cilia Genes in Pancreatic Cancer

    To identify genes regulated by SOX9, researchers performed siRNA knockdown of SOX9 followed by RNA-seq in PANC-1 cells, a human PDAC cell line.
    [Human Molecular Genetics]

    Abstract

    Elevated Levels of Mitochondrial CoQ10 Induce ROS-Mediated Apoptosis in Pancreatic Cancer

    Investigators demonstrated that delivery of oxidized Coenzyme Q10 increased mitochondrial Q-pool and was associated with an increase in reactive oxygen species (ROS) generation, effectuating anti-cancer effects in a pancreatic cancer model.
    [Scientific Reports]

    Full Article

    Watch a webinar on using patient-derived iPS cells to model diabetes.
    REVIEWS

    Pregnancy-Induced Changes in β-Cell Function: Who Are the Key Players?

    Investigators examine how placental and maternal hormones work cooperatively to activate several signaling pathways, transcription factors, and epigenetic regulators to drive adaptations in β‐cell function during pregnancy.
    [Journal of Physiology]

    AbstractFull Article

    INDUSTRY AND POLICY NEWS

    Oramed Reaches 25% Randomization in World’s First Phase III Oral Insulin Study Conducted under FDA Approved Protocol

    Oramed Pharmaceuticals, Inc. announced that it has enrolled and randomized 25% of the 675 patients planned for its Phase III ORA-D-013-1 study of its oral insulin capsule ORMD-0801 for the treatment of type 2 diabetes.
    [Oramed Pharmaceuticals, Inc.]

    Press Release

    Evolve BioSystems, Inc. Announces the Use of Activated B. infantis EVC001 by International Consortium to Study the Prevention of Type 1 Diabetes in Children

    Evolve BioSystems, Inc. announced that its product, activated B. infantis EVC001, will be used in one of the largest international clinical studies on preventing type 1 diabetes in genetically predisposed children. The randomized, controlled, double-blind, multicenter trial will be conducted across eight major research centers in five European countries.
    [Evolve BioSystems, Inc.]

    Press Release

    FEATURED EVENT

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    June 14 – 18, 2021
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    JOB OPPORTUNITIES

    Postdoctoral Position – Adipocyte Biology Research

    Harvard Medical School – Boston, Massachusetts, United States,

    Postdoctoral Fellowship – Diabetes Research

    University of Michigan – Ann Arbor, Michigan, United States

    Faculty and Postdoctoral Positions – Stem Cells and Cancer

    Shanghai Jiao Tong University School of Medicine- Shanghai, China

    Postdoctoral Scientist – Senescence and Cancer

    Cancer Research Center of Lyon – Lyon, France

    Senior Scientist – Assay Development

    CyberCoders – San Diego, California, United States

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