 | | Vol. 12.14 – 13 April, 2021 |
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| Investigators showed that inhibiting serpinB13, a cathepsin L protease inhibitor expressed in the pancreatic epithelium, caused in vitro and in vivo cleavage of the extracellular domain of Notch1.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that Pbk, a serine/threonine protein kinase, was essential for high fat diet‐induced beta cell proliferation in vivo using a Pbk kinase deficiency knock‐in mouse model.
[EMBO Molecular Medicine] |
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| Investigators analyzed the role of Cox6a2 in pancreatic β-cell function and its pathophysiological significance in diabetes mellitus.
[Biochemical and Biophysical Research Communications] |
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| The authors explored the possible beneficial effects of vitexin on high glucose-induced cytotoxicity in pancreatic β-cells. The INS-1 pancreatic β-cell line was used in this study.
[Archives of Physiology and Biochemistry] |
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| Using in vitro and in vivo pancreatic cancer models, scientists showed that IDO1 expression was highly context dependent, influenced by attachment-independent growth and the canonical activator IFNγ.
[Molecular Cell] |
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| Investigators provided evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human PDAC. Targeted deletion of SLFN5 resulted in decreased PDAC cell proliferation and suppressed PDAC tumorigenesis in in vivo PDAC models.
[Oncogene] |
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| Researchers report dynamic metabolic reprogramming in immortalized human non-cancerous pancreatic ductal epithelial cells.
[Cancer Gene Therapy] |
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| The authors engineered a high affinity soluble human leukemia inhibitory factor (LIF) receptor decoy that sequestered human LIF and inhibited its signaling as a therapeutic strategy.
[Communications Biology] |
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| Scientists demonstrated that NR5A2 acted as a negative prognostic biomarker in PDAC. NR5A2 silencing inhibited the proliferation and migration abilities of pancreatic cancer cells in vitro and in vivo.
[Cell Death Discovery] |
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| Cultured pancreatic stellate cells were found to secrete high levels of activin A resulting in PDAC cell migration that was abolished by anti-activin A neutralizing antibody.
[Scientific Reports] |
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| Scientists discuss the discoveries that have led to the current understanding of how insulin promotes glucose uptake in muscle.
[Cell Metabolism] |
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| The University of Texas MD Anderson Cancer Center and TriSalus Life Sciences®, announced a strategic research collaboration to evaluate the treatment of tumors of the pancreas and liver by integrating interventional delivery of SD-101, an investigational toll-like receptor 9 agonist, in combination with checkpoint inhibition immunotherapy.
[TriSalus Life Sciences] |
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| Provention Bio, Inc. has announced that the company received a notification from the FDA, stating that, as part of its ongoing review of the company’s Biologic License Application for teplizumab for the delay or prevention of clinical type 1 diabetes, the FDA has identified deficiencies that preclude discussion of labeling and post-marketing requirements/commitments at this time.
[Provention Bio, Inc.] |
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| November 29 – December 1, 2021
Barcelona, Spain |
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| | Johns Hopkins All Children’s Hospital – St. Petersburg, Florida, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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