 | | Vol. 12.16 – 27 April, 2021 |
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| Researchers investigated how the adult pancreas maintained tissue health in vivo following sporadic expression of oncogenic Kras (KrasG12D), the key driver mutation in human pancreatic cancer.
[Current Biology] |
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 | | DIABETES AND PANCREATITIS |
| | Investigators showed that acute blockade of the milk fat globule epidermal growth factor like 8 (MFGE8/β5) pathway enhanced while acute augmentation dampened insulin-stimulated glucose uptake.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that regenerating family member 4 (Reg4) knockdown significantly impaired pancreatic regeneration after pancreatitis.
[Journal of Cellular Physiology] |
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| Scientists investigated the potential involvement of hsa_circ_0054633 in high glucose‑induced diabetic model and its potential mechanism.
[Diabetes Research and Clinical Practice] |
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| Scrt1 expression was controlled by the transcriptional repressor RE-1 silencing transcription factor and was increased in an in vitro reprogramming system of pancreatic exocrine cells to β-like cells.
[Scientific Reports] |
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| The levels of miR-335-5p and solute carrier family 2 member 4 (SLC2A4) in blood samples collected from patients with type 2 diabetes and pancreatic cell lines were measured by real time quantitative PCR.
[Biochemical and Biophysical Research Communications] |
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| Scientists generated pancreatic cancer cells resistant to Mek1/2 inhibition, which were also resistant to KRAS and Erk1/2 inhibitors.
[Cancer Research] |
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| INS-1E beta-cells incubated with serum from trained mice displayed similar pattern of insulin secretion and gene expression than isolated islets from trained mice.
[Scientific Reports] |
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| Researchers evaluated the function of miR‐125b and the mechanism involved in pancreatic cancer. They showed that expression of miR‐125b was elevated in pancreatic cancer cells and tissues and was correlated to proliferation and migration of cells.
[Journal of Biochemical and Molecular Toxicology] |
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| The authors provide an overview of the recent developments in different in vitro and in vivo models, which aim to recapitulate the complexity of pancreatic ductal adenocarcinoma in a laboratory environment, as well to describe how 3D in vitro models can be included into drug development pipelines that are already including sophisticated in vivo models.
[Advanced Drug Delivery Reviews] |
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| Scientists highlight relevant studies involving iPSC-β cells and progenitors, encompassing new conclusions involving cells from patients with diabetes and the therapeutic potential of iPSC-β cells.
[Cell Reports Medicine] |
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| Fractyl Laboratories, Inc. announced that the US FDA has granted Breakthrough Device Designation for Revita® DMR in patients with insulin-treated type II diabetes.
[Fractyl Laboratories, Inc.] |
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| ProtoKinetix announced Phase I clinical trials of AAGP® treated islet cells have resumed at the University of Alberta, Edmonton.
[ProtoKinetix, Inc. (Business Wire, Inc.)] |
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| January 12 – 14, 2022
Shanghai, China |
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| Francis Crick Institute – London, England, United Kingdom |
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| Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Baylor Scott and White Research Institute – Dallas, TX, United States |
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| | Johns Hopkins All Children’s Hospital – St. Petersburg, Florida, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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