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| Scientists differentiated human pluripotent stem cells into pancreatic duct-like organoids with morphological, transcriptional, proteomic, and functional characteristics of human pancreatic ducts, further maturing upon transplantation into mice.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that hyperactivation of the tyrosine phosphatase SHP2 found in Noonan syndrome led to an unsuspected insulin resistance profile uncoupled from altered lipid management in both patients and mice. .
[Science Translational Medicine] |
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| The CRL neddylation inhibitor Pevonedistat/MLN4924 stabilized ETV5 and remediated the hyperinsulinemia and obesity/diabetes phenotypes of mice.
[Nature Communications] |
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| Investigators evaluated the toxic effect of glyceraldehyde-derived intracellular AGEs on normal and malignant pancreatic ductal cells by assessing the cell viability, toxicity, and oxidative stress, followed by proteomic analysis.
[Cells] |
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| INS-1 cells were treated with autoantibody against the angiotensin II type I receptor, and cell viability, apoptosis, and autophagy-related proteins were detected by cell counting kit-8 assay, flow cytometry, and western blot analysis, respectively.
[Acta Biochimica et Biophysica Sinica] |
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| Researchers identified that the SF3B1 K700E mutation was strongly associated with tumor growth in pancreatic ductal adenocarcinoma.
[Molecular Oncology] |
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| Scientists found that genetic deficiency for protease‐activated receptor 1(PAR1) increased acinar gene expression programs in the healthy pancreas and that PAR1 deficiency limited ductal transdifferentiation in experimental systems for acinar‐to‐ductal metaplasia.
[Molecular Oncology] |
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| Researchers showed evidence that suppression of acid alpha‐glucosidase, one of the lysosomal enzymes, improveed chemosensitivity and exerted apoptotic effects on pancreatic cancer cells through the disturbance of expression of the transcription factor EB.
[Cancer Science] |
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| The authors showed that Fzd7/Wnt7b knockdown could reduce pancreatic ductal adenocarcinoma cell stemness and chemoresistance by reducing the percentage of cancer stem cells.
[Cancer Medicine] |
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| Drugs that augment insulin sensitivity, stimulate insulin secretion or the incretin axis, or suppress hepatic glucose production are active in more than 7,000 global trials using new mechanisms of action.
[Nature Reviews Endocrinology] |
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| Researchers analyzed the existing knowledge on the role of transient receptor potential channels (TRP) channels in the development and progression of pancreatic ductal adenocarcinoma.
[Cells] |
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| Xeris Pharmaceuticals, Inc., announced that the United Kingdom’s Medicines and Healthcare Regulatory Agency has approved Ogluo® injection for the treatment of severe hypoglycaemia in adults, adolescents, and children aged two years and over with diabetes mellitus
[Xeris Pharmaceuticals, Inc. (Business Wire, Inc.)] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Baylor Research Institute – Dallas, TX, United States |
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| | Johns Hopkins All Children’s Hospital – St. Petersburg, Florida, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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