 | | Vol. 12.18 – 11 May, 2021 |
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| Researchers devised a subcutaneous injectable acellular pancreatic extracellular matrix platform for localizing the bioengineered β cells while creating a pancreas‐like immunogenic microenvironment, in which the autoreactive T cells could interface with the β cells.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To isolate β cell precursors from late stage pancreatic endocrine progenitor cells derived from iPS cells, researchers have identified CD82, a member of the tetraspanin family.
[Scientific Reports] |
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| Researchers assessed the actions of JMV-449 on pancreatic beta-cells alone, and in combination with glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.
[Biochimica Et Biophysica Acta-General Subjects] |
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| Scientists examined the expression of other Family B Gs‐protein coupled receptor in the cell line and assessed cAMP elevation and neuritogenesis after treatment with their cognate peptide ligands.
[Journal of Neuroendocrinology] |
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| Using functional genomics and subsequent in vitro and in vivo validations, investigators found that pancreatic ductal adenocarcinoma cell lines with high NADPH levels were dependent on peroxiredoxin 4 for their growth and survival.
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| Researchers found that BM-MSC-derived exosomes significantly reduced the invasion, migration, and proliferation of pancreatic cancer cells, as well as tumor stemness.
[Cancer Letters] |
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| Investigators showed that an induced pluripotent stem cell (iPSC)-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8+ T cell effector and memory responses, induced cancer-specific humoral immune responses, reduced immunosuppressive CD4+ T regulatory cells, and prevented tumor formation in 75% of pancreatic ductal adenocarcinoma mice.
[Stem Cell Reports] |
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| Researchers developed a six-tier grading scheme for neoadjuvant responses evaluating the remaining tumor cells in surgical specimens.
[Scientific Reports] |
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| Scientists presented the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells.
[Scientific Reports] |
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| The authors describe the evidence of an association and causal link between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), discusses the putative pathophysiological mechanisms linking NAFLD to T2DM and summarizes the current pharmacological treatments for NAFLD or T2DM that might benefit or adversely affect the risk of T2DM or NAFLD progression.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists elucidate the roles of calcium and ATP in the control of the normal functions of the different cell types in the exocrine pancreas as well as the roles of these molecules in the pathophysiology of acute pancreatitis.
[Physiological Reviews] |
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| Bigfoot Biomedical, Inc. announced that the FDA has granted 510(k) clearance for first-of-its-kind Bigfoot Unity™ Diabetes Management System, which features connected smart pen caps that recommend insulin doses for people using multiple daily injection therapy.
[Bigfoot Biomedical, Inc. (Business Wire, Inc.)] |
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| May 25 – 27, 2022
Hinxton, England, United Kingdom |
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| | University of California Davis – Davis, California, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Baylor Research Institute – Dallas, TX, United States |
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| | Johns Hopkins All Children’s Hospital – St. Petersburg, Florida, United States |
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