 | | Vol. 12.19 – 18 May, 2021 |
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| Researchers found that the SARS-CoV-2 receptor, ACE2 and related entry factors were expressed in β-cells, with selectively high expression of NRP1.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| RNA-sequencing analysis showed a comprehensive downregulation of β cell and α cell identity genes in A-485-treated islets, without upregulation of dedifferentiation markers and derepression of disallowed genes.
[Cell Death & Disease] |
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| Investigators applied a glycoproteomic approach to identify proteoglycans, their glycosaminoglycan chains and their attachment sites in insulin-secreting cells.
[Glycobiology] |
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| To model metastatic dissemination of tumor cells, human pancreatic neuroendocrine neoplasms cell lines stably expressing firefly luciferase were generated and introduced into NSG immunodeficient mice by intracardiac or intravenous injection.
[Scientific Reports] |
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| Researchers demonstrated that equilibration of mouse islets with small molecules in aqueous solutions could be accelerated from greater than 24 to 6 hours by increasing incubation temperature to 37 °C.
[Scientific Reports] |
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| Scientists used rat primary islet cells and MIN6 mouse beta cell line to investigate TNF-related apoptosis-inducing ligand (TRAIL)-induced proliferation.
[Journal of Molecular Endocrinology] |
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| Methotrexate, which is recognized as a refractory drug for pancreatic cells, was conjugated to the surface of LiYF4:Ce3+ nanoparticles through a photocleavable linker molecule.
[ACS Nano] |
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| Glycogen synthase kinase-3 β (GSK3β) was identified as a downstream target of PFKFB4 and an PFKFB4-interacting protein.
[Pharmacological Research] |
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| Researchers indicated that a high level of glucose exposure does not effect the invasion and migration of PANC-1 cells, while aspartame increased both of these aggressiveness criteria.
[Food and Chemical Toxicology] |
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| Investigators found that the histone acetyltransferases inhibitor C646 augmented anti-tumor effects in vitro by inhibiting cell proliferation and cell cycle progression concomitantly with suppression of acetylated H3K9 and H3K27 expression.
[Scientific Reports] |
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| In vitro functional experiments showed that LINC00173 overexpression inhibited the proliferation and invasion of pancr
[DNA and Cell Biology] |
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| The review summarizes the progress in understanding the role of Yin-Yang 1 (YY1) in pancreatic endocrine and exocrine tumors and provides a reasonable assessment of the potential for therapeutic targeting of YY1 in pancreatic tumors.
[Cell and Bioscience] |
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| AzurRx BioPharma, Inc., announced positive interim data from the first 18 out of 20 patients in its Phase II trial evaluating MS1819 in combination with the current standard of care, porcine-derived pancreatic enzyme replacement therapy (PERT), for the treatment of severe exocrine pancreatic insufficiency in patients with cystic fibrosis.
[AzurRx BioPharma, Inc. (Globenews Wire, Inc.)] |
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| May 25 – 27, 2022
Hinxton, England, United Kingdom |
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| | Vertex Pharmaceuticals Incorporated – Watertown, New York, United States |
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| | University of California Davis – Davis, California, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Baylor Research Institute – Dallas, TX, United States |
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