Pancreatic Cell News Volume 12.20 | May 25 2021

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    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.20 – 25 May, 2021
    TOP STORY

    SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation

    Researchers described the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19.
    [Cell Metabolism]

    Full Article

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal
    DIABETES & PANCREATITIS

    Orphan GPR116 Mediates the Insulin Sensitizing Effects of the Hepatokine FNDC4 in Adipose Tissue

    Scientists found that the liver primarily controlled the circulating levels of soluble FNDC4 and lowering of the hepatokine FNDC4 led to prediabetes in mice.
    [Nature Communications]

    Full Article

    Decreased GLUT2 and Glucose Uptake Contribute to Insulin Secretion Defects in MODY3/HNF1A hiPSC-Derived Mutant β Cells

    Investigators utilized maturity onset diabetes of the young 3 (MODY3) patient-derived human induced pluripotent stem cells (hiPSCs) to study the effect(s) of a causal HNF1A+/H126D mutation on pancreatic function.
    [Nature Communications]

    Full Article

    The Autophagy Protein Becn1 Improves Insulin Sensitivity by Promoting Adiponectin Secretion via Exocyst Binding

    Scientists unveiled a metabolically important non-cell-autonomous, non-degradative mechanism regulated by the essential autophagy protein Becn1 in adipose tissue.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Live-Cell Imaging of Glucose-Induced Metabolic Coupling of β and α Cell Metabolism in Health and Type 2 Diabetes

    Researchers used phasor – Fluorescence Lifetime Imaging Microscopy to monitor oxidative phosphorylation and glycolysis in living islet cells before and after glucose stimulation.
    [Communications Biology]

    Full Article

    In Vivo Screen Identifies a SIK Inhibitor That Induces β Cell Proliferation through a Transient UPR

    Single-cell transcriptomic analyses of mouse β cells demonstrate that HG-9-91-01 induced a wave of activating transcription factor 6-dependent unfolded protein response (UPR) before cell cycle entry.
    [Nature Metabolism]

    Full Article

    PANCREATIC CANCER

    Pancreatic Cancer Prognosis Is Predicted by an ATAC-Array Technology for Assessing Chromatin Accessibility

    By ATAC-seq analyses of EpCAM+ pancreatic ductal adenocarcinoma malignant epithelial cells sorted from 54 freshly resected human tumors, researchers showed the discovery of a signature of 1092 chromatin loci displaying differential accessibility between patients with disease free survival (DFS) less than 1 year and patients with DFS greater than 1 year.
    [Nature Communications]

    Full Article

    Oncogenic KRAS Engages an RSK1/NF1 Pathway to Inhibit Wild-Type RAS Signaling in Pancreatic Cancer

    Investigators used proximity labeling to identify protein interactors of active KRAS in pancreatic ductal adenocarcinoma (PDAC) cells. They expressed fusions of wild-type (BirA-KRAS4B), mutant (BirA-KRAS4BG12D), and nontransforming cytosolic double mutant (BirA-KRAS4BG12D/C185S) KRAS with the BirA biotin ligase in murine PDAC cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Patient-Derived Tumor Xenograft and Organoid Models Established from Resected Pancreatic, Duodenal and Biliary Cancers

    Patient-derived xenograft models were established from 276 pancreato-duodenal and biliary cancer resections. Pancreatic ductal adenocarcinoma (PDAC), had a P0 engraftment rate of 62%.
    [Scientific Reports]

    Full Article

    Watch a webinar on using patient-derived iPS cells to model diabetes.
    REVIEWS

    A Selective Look at Autophagy in Pancreatic β-Cells

    The authors examine the unique molecular players underlying each distinct form of autophagy in β-cells, including selective autophagy of mitochondria, insulin granules, lipid, intracellular amyloid aggregates, endoplasmic reticulum, and peroxisomes.
    [Diabetes]

    Abstract

    Glucose-Induced Insulin Secretion in Isolated Human Islets: Does It Truly Reflect β-Cell Function In Vivo?

    The aims of the review are not to discuss specificities of pathways controlling secretion but to compare qualitative and quantitative features of glucose-induced insulin secretion in isolated human islets and in living human subjects.
    [Molecular Metabolism]

    Full Article

    INDUSTRY AND POLICY NEWS

    Zealand Pharma Receives First FDA Approval and Prepares for Launch of Zegalogue® (Dasiglucagon) Injection

    Zegalogue, Inc. received approval from US FDA for Zegalogue® (dasiglucagon) injection, for the treatment of severe hypoglycemia in people with diabetes. Zegalogue has been approved in pediatric and adult patients with diabetes aged 6 years and in adults with type-1 diabetes.
    [Zegalogue. Inc. (Globenews Wire, Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells and Regenerative Medicine

    January 12 – 14, 2022
    Shanghai, China

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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Pancreatic Development and Stem Cells

    King’s College London – London, England, United Kingdom

    Research Associate – Gene Editing

    Vertex Pharmaceuticals Incorporated – Watertown, New York, United States

    Postdoctoral Research Scholar – Immunology, Type 1 Diabetes

    University of California Davis – Davis, California, United States

    Postdoctoral Fellow – Diabetes

    Karolinska Institutet – Stockholm, Sweden

    Head of Department – Gastrointestinal Cancer

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    > See All Jobs

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