 | | Vol. 12.21 – 1 June, 2021 |
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| Reserachers described and validated the use of the SUrface SEnsing of Translation approach to demonstrate through FACS and Western Blot that glucose increased protein translation in the human cell line EndoC-βH2.
[Journal of Biological Chemistry] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Utilizing Min6 cells, a pancreatic ß-cell model, scientists knocked down G-protein coupled receptor kinase 2 (GRK2) and measured glucose-mediated intracellular calcium responses and insulin secretion.
[Scientific Reports] |
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| Islets were kept intact or dispersed into single cells and cultured in the presence of harmine, glucose, or heparin-binding epidermal growth factor-like growth factor (HB-EGF), and subsequently analyzed by immunohistochemistry or flow cytometry.
[Scientific Reports] |
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| Researchers investigated the effect of a cytidine deaminase inhibitor – Zebularine on anticancer activity of Gemcitabine in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research] |
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| Panc-1 cells demonstrated the intermediate characteristics of MIA PaCa-2 and BxPC3 on artificial human peritoneal tissue.
[Journal of surgical research] |
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| Investigators reported that Apolipoprotein E (ApoE) was elevated in peripheral blood monocytes in pancreatic ductal adenocarcinoma patients, and plasma ApoE protein levels stratified patient survival.
[Cancer Research] |
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| Scientists re-analyzed multiple pancreas and pancreatic ductal adenocarcinoma single-cell RNA-seq datasets and found a subset of non-malignant acinar cells, which they refered to as acinar edge cells, whose transcriptomes highly diverged from a typical acinar cell in each dataset.
[Cancer Research] |
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| Researchers searched for a gene signature that discriminate localized pancreatic ductal adenocarcinoma (PDAC) from confirmed metastatic PDAC and devised a preclinical protocol using circulating cell-free DNA (cfDNA) as an early biomarker of micro-metastatic disease to validate the identification of key signaling events.
[EMBO Molecular Medicine] |
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| Investigators assessed the anti-tumor effects of probiotic bacteria against pancreatic cancer cells. Among the known probiotic bacteria, Aspergillus oryzae exhibited a strong pancreatic tumor suppression effect.
[Scientific Reports] |
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| Scientists review emerging evidence that developmental and homeostatic regulation of β-cell function involves collaboration between lineage-determining and signal-dependent transcription factors.
[Trends in Endocrinology and Metabolism] |
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| The authors review recent advances in the fields of pancreas development and lineage reprogramming, and highlight fundamental challenges that need to be overcome to advance lineage reprogramming for generating pancreatic cells.
[Current Opinion in Genetics & Development] |
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| DayTwo, Inc. announced that it has launched a unique methodology for addressing depression in people with diabetes. The new solution, called EATS™ uses psychological techniques to overcome emotional barriers to chronic condition management.
[DayTwo, Inc. (Business Wire, Inc.)] |
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| September 7 – 11, 2022
Woods Hole, Massachusetts, United States |
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| German Research Center for Environmental Health – Neuherberg, Germany |
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| King’s College London – London, England, United Kingdom |
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| Vertex Pharmaceuticals Incorporated – Watertown, New York, United States |
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| University of California Davis – Davis, California, United States |
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| Karolinska Institutet – Stockholm, Sweden |
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