 | | Vol. 12.22 – 8 June, 2021 |
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| To search other possible mechanisms, scientists found the mRNA level and protein level of MKP7 were dramatically reduced in pancreatic β cells in the islets from NR4A1 knockout mice compared with that from wild type mice.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The activity of glutathione reductase and the levels of reduced glutathione and oxidised glutathione were assessed using assay kits.
[Journal of Pharmacy and Pharmacology] |
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| Min6 cells were induced by 5 mg/dl uric acid and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.
[Biochemical Genetics] |
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| Researchers showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
[Nature Biomedical Engineering] |
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| The authors identified valosin-containing protein as a regulator of p53-R273H by conducting immunoprecipitation-tandem mass spectrometry analysis. Valosin-containing protein bound p53-R273H at its DNA binding domain.
[Cancer Research] |
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| The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids] |
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| Researchers hypothesized that a new drug delivery system comprising chondroitin sulfate hydrogels loaded with sunitinib suppressed tumor growth in PanNET cells.
[Translational Research] |
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| Scientists performed secretome analyses of culture media of mouse pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma cells using Stable Isotope Labeling by Amino acid in Cell culture with click chemistry and liquid chromatography-mass spectrometry.
[Cellular Oncology] |
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| Investigators found that high expression of miR-194-5p in human pancreatic cancer patients was associated with a better survival rate, while increased expression of programmed cell death ligand 1 in human pancreatic cancer patients was associated with a worse survival rate.
[International Immunopharmacology] |
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| Researchers observed for the first time that miR-33a-5p expression level was significantly decreased in pancreatic ductal adenocarcinoma tissues and cell lines.
[Cellular & Molecular Biology Letters] |
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| Investigators discuss and focus on the pathological and molecular features of precancerous lesions of the pancreas, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, which are target lesions of early detection approaches.
[Nature Reviews Gastroenterology & Hepatology] |
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| Given the vast developments within this field, scientists review the wide-ranging and most current information related to pancreatic cancer genomics with the goal of integrating this information into a unifying description of the life history of pancreatic cancer.
[Nature Reviews Gastroenterology & Hepatology] |
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| Aimmune Therapeutics, Inc. announced the launch of PACT-CP, a Patient-Centric Chronic Pancreatitis Registry study to better understand the unmet needs and therapeutic burden on patients with EPI due to chronic pancreatitis.
[Aimmune Therapeutics, Inc. (BusinessWire, Inc.)] |
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| June 21 – 24, 2021
Virtual |
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| | Columbia University Irving Medical Center – New York, NY, United States |
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| | German Research Center for Environmental Health – Neuherberg, Germany |
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| | King’s College London – London, England, United Kingdom |
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| | Vertex Pharmaceuticals Incorporated – Watertown, New York, United States |
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| | University of California Davis – Davis, California, United States |
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