Pancreatic Cell News Volume 12.23 | Jun 15 2021

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    2021-06-15 | Volume 12.23


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.23 – 15 June, 2021
    TOP STORY

    Fine-Mapping, Trans-Ancestral and Genomic Analyses Identify Causal Variants, Cells, Genes and Drug Targets for Type 1 Diabetes

    Researchers reported the largest and most diverse genetic study of type 1 diabetes to date, yielding 78 genome-wide-significant regions, including 36 that were new.
    [Nature Genetics]

    Abstract

    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    NADK Is Activated by Oncogenic Signaling to Sustain Pancreatic Ductal Adenocarcinoma

    Scientists showed that oncogenic KRAS promoted protein kinase C-mediated NAD+ kinase (NADK) phosphorylation, leading to its hyperactivation, thus sustaining both NADP+ and NADPH levels in pancreatic ductal adenocarcinoma cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Peripherally Active Dextromethorphan Derivatives Lower Blood Glucose Levels by Targeting Pancreatic Islets

    Investigators showed that basic nitrogen-containing residues blocked central adverse events of dextromethorphan without reducing its anti-diabetic effects, including the protection of human pancreatic islets from cell death.
    [Cell Chemical Biology]

    Abstract

    Necroptosis Protects against Exacerbation of Acute Pancreatitis

    Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.
    [Cell Death & Disease]

    Full Article

    SETD4-Expressing Cells Contribute to Pancreatic Development and Response to Cerulein Induced Pancreatitis Injury

    Scientists provided a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SET domain-containing protein 4 (SETD4)+ cell population.
    [Scientific Reports]

    Full Article

    TP53 Missense Mutations in PDAC Are Associated with Enhanced Fibrosis and an Immunosuppressive Microenvironment

    Researchers show that silencing of endogenous mutp53 in KPC cells, derived from mouse PDAC tumors driven by mutant Kras and mutp53, down-regulated fibrosis and elevated CD8+ T cell infiltration in the tumors arising upon orthotopic injection of these cells into the pancreas of syngeneic mice.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    CF33-hNIS-antiPDL1 Virus Primes Pancreatic Ductal Adenocarcinoma for Enhanced Anti-PD-L1 Therapy

    Oncolytic viral chimera, CF33-hNIS-antiPDL1 genetically modified to express anti-human PD-L1 antibody and CF33-hNIS-Δ without the anti-PD-L1 gene, were used to investigate the immunogenic effects of oncolytic virus and virus-delivered anti-PD-L1 in pancreatic ductal adenocarcinoma in vitro.
    [Cancer Gene Therapy]

    Abstract

    Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ

    Scientists found that EPCAM + tumors developed in the mouse pancreas stored zinc that was detectable by fluorescence-activated cell sorting using N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide (TSQ), a fluorescence chelator. EPCAM + TSQ + tumor cells isolated from the mouse pancreas formed organoids in matrigel.
    [Biological Trace Element Research]

    Abstract

    Combinations of Phytochemicals More Efficiently than Single Components Activate Nrf2 and Induce the Expression of Antioxidant Enzymes in Pancreatic Cancer Cells

    Human pancreatic cancer cells MIA-Pa-Ca-2 were treated with the phytochemicals alone or their equimolar mixture for 24 hours and activation of Nrf2 and expression of its target genes were evaluated.
    [Nutrition and Cancer-An International Journal]

    Abstract

    How to prioritize and manage your research projects
    REVIEWS

    The Biological Underpinnings of Therapeutic Resistance in Pancreatic Cancer

    The authors discuss recent advances in the understanding of the biological underpinnings of pancreatic ductal adenocarcinoma and their implications as targetable vulnerabilities in this highly lethal disease.
    [Genes & Development]

    Abstract

    Ptf1a Function and Transcriptional Cis-Regulation, a Cornerstone in Vertebrate Pancreas Development

    Investigators present a brief overview of vertebrate pancreas development, centered on Ptf1a function and transcriptional regulation, covering similarities and divergences in three broadly studied organisms: human, mouse, and zebrafish.
    [FEBS Journal]

    Abstract

    INDUSTRY AND POLICY NEWS

    Diabetes Center Berne Launches Its First Open Innovation Challenge and Supports the Most Promising Ideas Submitted with Coaching, Expertise and a Total of 200,000 USD in Funding

    DCB is looking for innovators, co-creators, scientists and members of the diabetes community from around the world to join our open call for ideas and be part of an innovative community at the forefront of diabetes technology.
    [Diabetes Center Berne (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Cell Size and Growth Regulation

    June 21 – 24, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Mouse Genetics

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Scientist – Type I Diabetes

    Columbia University Irving Medical Center – New York, NY, United States

    PhD Candidate – Non-Invasive Glucose Sensing

    German Research Center for Environmental Health – Neuherberg, Germany

    Postdoctoral Research Associate – Pancreatic Development and Stem Cells

    King’s College London – London, England, United Kingdom

    Research Associate – Gene Editing

    Vertex Pharmaceuticals Incorporated – Watertown, New York, United States

    > See All Jobs

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