 | | Vol. 12.24 – 22 June, 2021 |
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| Researchers constructed a multidimensional map of β cell transcriptional trajectories during the normal course of β cell postnatal development and during their dedifferentiation in models of both type I diabetes and type II diabetes.
[Diabetes] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a transcriptome-wide profiling approach to map translation initiation start sites in human beta-cells under standard and inflammatory conditions, the authors identified a completely new set of polypeptides derived from non-canonical start sites and translation initiation within lncRNA.
[Diabetes] |
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| The pancreas was analyzed by histology, immunochemistry staining, and TUNEL assays, and the expression of certain proteins and RNAs, cytokine levels, trypsin activity, and reactive oxygen species (ROS) levels were determined.
[Cell Death & Disease] |
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| Chronic pancreatitis (CP) is a fibro-inflammatory disease in which recurrent pancreatic inflammation leads to pancreatic fibrosis. Scientists investigated the role of discoidin domain receptors in CP.
[Scientific Reports] |
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| The effects of prodrug 1 were studied in lipopolysaccharide-induced in vitro and in vivo apoptosis and pancreatitis models by determining the cellular apoptotic levels with human umbilical vein endothelial cells and pancreatic caspase-3/-7 activity in mice.
[Chemico-Biological interactions] |
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| Investigators suggested that nicotine has the potential to facilitate pancreatic fibrosis in chronic pancreatitis. They analyzed the function and mechanism of nicotine on pancreatic stellate cells and pancreatic fibrosis in rats.
[Toxicology Letters] |
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| LINC00842 expression was upregulated in PDAC and induced by high concentration of glucose via transcription factor YY1.
[Nature Communications] |
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| Reserachers showed inhibition of glucose metabolism with low dose 2-deoxyglucose in combination with a MEK inhibitor induced apoptosis in KrasG12D-driven PDAC in vitro.
[Cancer Research] |
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| Scientists presented evidence that polo-like kinase 1 (Plk1) was a novel substrate of vaccinia-related kinase 2, a serine-threonine kinase that was highly expressed and predicted poor prognosis in pancreatic cancer.
[Oncogene] |
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| The design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets, highlighting distinct design parameters.
[Advanced Science] |
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| Investigators discuss the anatomy and physiology of the pancreas, and identify the clinical considerations for engineering a bioartificial pancreas.
[Trends in Endocrinology and Metabolism] |
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| The authors review recent efforts about standardized imaging features and reporting of chronic pancreatitis and recently published or ongoing imaging studies, which aim to establish novel imaging biomarkers for detection of parenchymal changes seen in chronic pancreatitis.
[Current Opinion in Gastroenterology] |
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| Imbria Pharmaceuticals, Inc. announced that the first ten patients were dosed in the IMPROVE-DiCE Phase IIa, open-label study of IMB-1018972 in patients with type II diabetes at risk of diabetic cardiomyopathy.
[Imbria Pharmaceuticals, Inc. (BusinessWire, Inc.)] |
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| Amalgam Rx, Inc., annocunced global expansion of its insulin titration solution with Novo Nordisk. With Amalgam’s recently received CE Mark for iSage Rx and Dose Check, Novo Nordisk is planning a global expansion.
[Amalgam Rx. Inc.] |
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| September 5 – 8, 2021
Exeter, England, United Kingdom |
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| Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Columbia University Irving Medical Center – New York, New York, United States |
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| German Research Center for Environmental Health – Neuherberg, Germany |
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| Vertex Pharmaceuticals Incorporated – Watertown, New York, United States |
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