Pancreatic Cell News Volume 12.25 | Jun 29 2021

    By
    Justin.choi
    -
    0
    31







    2021-06-29 | PACN 12.25


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.25 – 29 June, 2021
    TOP STORY

    Novel Enzymatic Cross-Linking–Based Hydrogel Nanofilm Caging System on Pancreatic β Cell Spheroid for Long-Term Blood Glucose Regulation

    Researchers demonstrated a multilayer hydrogel nanofilm caging strategy capable of protecting cells from high shear stress and reducing immune response by interfering cell-cell interaction.
    [Science Advances]

    Full Article

    Explore scientific events this July with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Oxytocin Signal Contributes to the Adaptative Growth of Islets during Gestation

    Gestating and non-gestating mice were used to evaluate the in vivo effect of oxytocin signal on β-cells during pregnancy. In vitro experiments were performed on INS-1 insulinoma cells.
    [Endocrine Connections]

    Full Article

    Multi-Omics Profiling of Living Human Pancreatic Islet Donors Reveals Heterogeneous Beta Cell Trajectories towards Type 2 Diabetes

    Scientists conducted a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum, from normoglycemia to type 2 diabetes.
    [Nature Metabolism]

    Abstract

    Targeting p130Cas- and Microtubule-Dependent MYC Regulation Sensitizes Pancreatic Cancer to ERK MAPK Inhibition

    Researchers determined that SRC-inhibitor-mediated suppression of p130Cas phosphorylation impaired MYC transcription through a DOCK1-RAC1-β-catenin-dependent mechanism.
    [Cell Reports]

    AbstractGraphical Abstract

    SOX9 Is a Critical Regulator of TSPAN8-Mediated Metastasis in Pancreatic Cancer

    The authors identified that upregulation of TSPAN8 expression in Pancreatic ductal adenocarcinoma facilitates metastasis in vivo and in vitro.
    [Oncogene]

    Full Article

    Pentraxin 3 Is a Stromally-Derived Biomarker for Detection of Pancreatic Ductal Adenocarcinoma

    In vitro and ex vivo analyses of pentraxin 3, in human PDAC samples, pancreatic stellate cells (PSCs), cell lines and transgenic mouse model for PDAC, suggested that pentraxin 3 originated from stromal cells, mainly PSCs.
    [npj Precision Oncology]

    Full Article

    LncRNA CERS6-AS1 Promotes Proliferation and Metastasis through the Upregulation of YWHAG and Activation of ERK Signaling in Pancreatic Cancer

    Scientists found that lncRNA CERS6-AS1 was highly expressed in pancreatic cancer tissues and cells. Additionally, high expression of CERS6-AS1 was obviously associated with poor prognosis.
    [Cell Death & Disease]

    Full Article

    Novel Circular RNA circSLIT2 Facilitates the Aerobic Glycolysis of Pancreatic Ductal Adenocarcinoma via miR-510-5p/C-Myc/LDHA Axis

    Researchers found that the novel circular RNA circSLIT2 was significantly upregulated in pancreatic ductal adenocarcinoma tissues and cells.
    [Cell Death & Disease]

    Full Article

    TNF-α Induces Endothelial–Mesenchymal Transition Promoting Stromal Development of Pancreatic Adenocarcinoma

    Scientists showed that TNF-α strongly induced human endothelial cells to undergo endothelial–mesenchymal transition (EndMT). They also showed that TNF-α-induced EndMT was reversible.
    [Cell Death & Disease]

    Full Article

    Circ-0005105 Activates COL11A1 by Targeting miR-20a-3p to Promote Pancreatic Ductal Adenocarcinoma Progression

    Scientists focused on the functional investigation of circ-0005105, a newly identified circular RNA, in pancreatic ductal adenocarcinoma progression.
    [Cell Death & Disease]

    Full Article

    KCNN4-Mediated Ca2+/MET/AKT Axis Is Promising for Targeted Therapy of Pancreatic Ductal Adenocarcinoma

    Researchers demonstrated that the level of KCNN4 in pancreatic ductal adenocarcinoma was abnormally elevated, and the overexpression of KCNN4 was induced by transcription factor AP-1.
    [Acta Pharmacologica Sinica]

    Abstract

    Porcine Pancreatic Ductal Epithelial Cells Transformed with KRASG12D and SV40T Are Tumorigenic

    Primary pancreatic epithelial cells were isolated from the pancreatic ducts of domestic pigs. A transformed cell line was generated from these primary cells with oncogenic KRAS and SV40T.
    [Scientific Reports]

    Full Article

    ON956-PneumaCult AOK Banner Ad-728x90-A.jpg
    REVIEWS

    Therapeutic Opportunities for Pancreatic β-Cell ER Stress in Diabetes Mellitus

    Scientists discuss the possible mechanisms responsible for endoplasmic reticulum (ER) proteostasis imbalance with a focus on type II diabetes mellitus, in which both genetics and environment are considered important in promoting ER stress in β-cells.
    [Nature Reviews Endocrinology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Adocia Initiates BC LisPram Phase I Clinical Trial in Pump for People with Type I Diabetes

    Adocia, Inc. announced the launch of a Phase I clinical study in collaboration with Dr. Ahmad Haidar, McGill University, Canada, to assess pharmacokinetic, glycemic control and safety of BioChaperone® Lispro Pramlintide prandial formulation in 16 people with type I diabetes compared to rapid insulin lispro.
    [Adocia, Inc.]

    Press Release

    Phase III Pivotal Trial of Once Weekly Exenatide in Adolescents Aged 10–17 Shows Benefit for the Treatment of Type 2 Diabetes

    Positive results from the Phase III pivotal trial showed AstraZeneca’s exenatide extended-release 2 mg once weekly significantly reduced blood sugar—as measured by HbA1c—versus placebo in adolescents aged 10–17 with type 2 diabetes.
    [AstraZeneca, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Cancer Immunometabolism

    November 29 – December 1, 2021
    Barcelona, Spain

    > See All Events

    JOB OPPORTUNITIES

    Post-Doctoral Fellow – Functional Genomics of Type II Diabetes

    Beth Israel Deaconess Medical Center – Cambridge, Massachusetts, United States

    Postdoctoral Fellowship – Cell Biology of Metabolic Regulation

    Harvard Joslin Diabetes Center – Boston, Massachusetts, United States

    Research Associate – Mouse Genetics

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Scientist – Type I Diabetes

    Columbia University Irving Medical Center – New York, NY, United States

    PhD Candidate – Non-Invasive Glucose Sensing

    German Research Center for Environmental Health – Neuherberg, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pancreatic Cell News Twitter