 | | Vol. 12.26 – 6 July, 2021 |
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| Researchers introduced SNAPf-tag into the N-terminal segment of GPR56 to enable monitoring of GPR56 cellular activity in situ.
[Molecular Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists screened the role of fetuin-A in survival of murine β-cells and validated the effect of fetuin-A release and lipid induced apoptosis in mouse insulinoma cell line MIN6.
[Journal of Cellular Physiology] |
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| Researchers revealed that angiopoietins, including angiopoietin-1 and angiopoietin-2 permitted the generation of islets from induced pluripotent stem cells with elevated glucose responsiveness, a hallmark of mature islets.
[Scientific Reports] |
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| Scientists found that an evolutionarily conserved region located approximately 40 kbp downstream of the transcription start site of Slc2a2 functioned as an active enhancer in the MIN6 β-cell line.
[Journal of Molecular Endocrinology] |
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| Researchers investigated the mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway in cultured cells and isolated mouse islets.
[Journal of Molecular Endocrinology] |
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| Gestating and non-gestating mice were used to evaluate the in vivo effect of oxytocin signal on β-cells during pregnancy. In vitro experiments were performed on INS-1 insulinoma cells.
[Endocrine Connections] |
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| Scientists conducted a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum, from normoglycemia to type 2 diabetes.
[Nature Metabolism] |
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| Researchers suggested that missense p53 mutations may have contributed to worse PDAC prognosis by promoting a more vigorous fibrotic tumor microenvironment and impeded the ability of the immune system to eliminate the cancer cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists screened multi-layer molecular data of 36 pancreatic cancer cell lines, including gene mutation, gene expression, miRNA expression, and protein profiles.
[Molecular Therapy-Nucleic Acids] |
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| Researchers detected the expression of interleukin‑28 receptor α subunit (IL‑28RA) in PDAC tissues using immunofluorescence staining and western blotting.
[International Journal of Oncology] |
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| Geranyl-2,4-dihydroxy-6-phenethylbenzoate (GDP), isolated from Boesenbergia pandurata rhizomes, exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition starvation conditions.
[Chemistry & Biodiversity] |
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| Scientists discuss the prospects and challenges in the clinical development of pancreatic cancer therapeutics.
[Signal Transduction and Targeted Therapy] |
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| Provention Bio, Inc. announced that the FDA has issued a CRL for the company’s BLA for teplizumab for the delay of clinical type 1 diabetes in at-risk individuals.
[Provention Bio, Inc.] |
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| September 5 – 8, 2021
Exeter, England, United Kingdom |
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| | University of Wisconsin-Madison, Wisconsin, Madison, United States |
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| | Beth Israel Deaconess Medical Center – Cambridge, Massachusetts, United States |
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| | Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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