Pancreatic Cell News Volume 12.27 | July 13 2021

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    2021-07-13 | PACN 12.27


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.27 – 13 July, 2021
    TOP STORY

    Single-Cell-Resolved Differentiation of Human Induced Pluripotent Stem Cells into Pancreatic Duct-Like Organoids on a Microwell Chip

    Researchers reported the single-cell characterization of the differentiation of pancreatic duct-like organoids from human induced pluripotent stem cells (hiPSCs) on a microwell chip that facilitated the uniform aggregation and chemical induction of hiPSC-derived pancreatic progenitors.
    [Nature Biomedical Engineering]

    Abstract

    Scientific resources to support your organoids research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Infection of the Pancreas Promotes Thrombo-Fibrosis and Is Associated with New-Onset Diabetes

    Scientists reported expression of angiotensin-converting enzyme 2 in pancreatic islet, ductal, and endothelial cells in non-human primates and humans.
    [JCI Insight]

    AbstractGraphical Abstract

    Pancreatic Extracellular Matrix/Alginate Hydrogels Provide a Supportive Microenvironment for Insulin-Producing Cells

    Hydrogel prepared with alginate and the pancreatic extracellular matrix was assessed for the beneficial outcomes on encapsulated insulin-producing cells.
    [ACS Biomaterials Science & Engineering]

    Abstract

    Effects of Growth Hormone-Releasing Hormone Agonistic Analog MR-409 on Insulin-Secreting Cells under Cyclopiazonic Acid-Induced Endoplasmic Reticulum Stress

    As the effects of GHRH and its agonists have not been fully elucidated in the beta cell, scientists proposed to investigate them by evaluating the role of the growth-hormone-releasing hormone agonist, MR-409, in cells under endoplasmic reticulum stress.
    [Molecular and Cellular Endocrinology]

    Abstract

    Erythropoietin Exposure of Isolated Pancreatic Islets Accelerates Their Revascularization after Transplantation

    Investigators hypothesized that erythropoietin exposure of isolated islets improved their posttransplant revascularization.
    [Acta Diabetologica]

    Full Article

    MEHP Induces Pyroptosis and Autophagy Alternation by Cathepsin B Activation in INS-1 Cells

    Scientists showed that mono-(2-ethylhexyl) phthalate (MEHP) decreased the cell viability of pancreatic beta-cell (INS-1 cells) in a concentration-dependent manner and induced pyroptosis at 400 μM.
    [Environmental Science and Pollution Research]

    Abstract

    Membrane Feature-Inspired Profiling of Extracellular Vesicles for Pancreatic Cancer Diagnosis

    By employing four antibodies specific to pancreatic cancer (PCa)-related membrane proteins, the AbMB–biChol platform enabled the successful differentiation and monitoring of PCa-related extracellular vesicles and distinguished PCa patients from healthy donors with improved efficacy, exhibiting superior efficiency over the analyses based on clinically used biomarker CA19-9 and PCa-related proteins.
    [Analytical Chemistry]

    Abstract

    C-Met-Targeted Near-Infrared Fluorescent Probe for Real-Time Depiction and Dissection of Perineural Invasion and Lymph Node Metastasis Lesions in Pancreatic Ductal Adenocarcinoma Xenograft Models

    c-Met-targeted near-infrared fluorescent probe for real-time visualization and dissection of pancreatic ductal adenocarcinoma, and corresponding perineural invasion and lymph node metastasis lesions.
    [Biomaterials Science]

    Abstract

    An Exosome-Mimicking Membrane Hybrid Nanoplatform for Targeted Treatment toward Kras-Mutant Pancreatic Carcinoma

    Scientists constructed a hybrid nanoplatform by fusing Celastrol-Loaded PEGylated lipids with the DC2.4 cell membrane to achieve targeted treatment of Kras-mutant pancreatic cancer.
    [Biomaterials Science]

    Abstract

    The Discovery of Indolone GW5074 during a Comprehensive Search for Non-Polyamine-Based Polyamine Transport Inhibitors

    Researchers presented the first comprehensive search for potential non-polyamine based polyamine transport inhibitors that work in human pancreatic cancer cells in vitro.
    [International Journal of Biochemistry & Cell Biology]

    Abstract

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    REVIEWS

    The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Pancreatic Cancer

    Researchers introduce the recent insights focusing on the discoveries of the relationship between exosomal RNAs and pancreatic cancer (PaCa), and the potentially diagnostic and therapeutic applications of exosomes in PaCa.
    [Cancer Cell International]

    Abstract

    INDUSTRY AND POLICY NEWS

    Teplizumab Awarded Innovation Passport in the United Kingdom (UK) for the Delay of Onset of Clinical Type 1 Diabetes in At-Risk Individuals

    Provention Bio, Inc., a biopharmaceutical company dedicated to intercepting and preventing immune-mediated disease, announced that teplizumab, an anti-CD3 monoclonal antibody, was awarded an Innovation Passport for the delay of clinical type I diabetes in at-risk individuals.
    [Provention Bio, Inc.]

    Press Release

    US FDA Approves Finerenone for the Treatment of Patients with Chronic Kidney Disease Associated with Type II Diabetes

    Bayer announced that the US FDA has approved finerenone, the first non-steroidal, selective mineralocorticoid receptor (MR) antagonist, under the brand name Kerendia®.
    [Bayer, Inc.]

    Press Release

    FEATURED EVENT

    Lymphocyte Antigen Receptor Signaling

    May 28 – June 1, 2022
    Castelnuovo Berardenga, Siena, Italy

    > See All Events

    JOB OPPORTUNITIES

    Assistant Research Scientist and Postdoctoral Research Associate – Diabetes

    Texas A&M University – College Station, Texas, United States

    Postdoctoral Fellow – Functional Genomics of Type II Diabetes

    Beth Israel Deaconess Medical Center – Cambridge, Massachusetts, United States

    Postdoctoral Fellowship – Cell Biology of Metabolic Regulation

    Harvard Joslin Diabetes Center – Boston, Massachusetts, United States

    Research Associate – Mouse Genetics

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Scientist – Type I Diabetes

    Columbia University Irving Medical Center – New York, NY, United States

    > See All Jobs

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