Pancreatic Cell News Volume 12.29 | Jul 27 2021

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    2021-07-27 | PACN 12.29


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.29 – 27 July, 2021
    TOP STORY

    AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53

    Pancreas-specific Agr2 ablation was performed to access its role in pancreatic carcinogenesis. Hydrophobic hexapeptides loaded in liposomes were developed to disrupt Agr2-RNAPII complex.
    [Gastroenterology]

    Abstract

    Watch a webinar on using patient-derived iPS cells to model diabetes.
    PUBLICATIONSRanked by the impact factor of the journal

    Pancreatic Ppy-Expressing γ-Cells Display Mixed Phenotypic Traits and the Adaptive Plasticity to Engage Insulin Production

    Scientists found that the γ-cell population was heterogeneous, with subsets of cells producing another hormone in addition to pancreatic polypeptide (Ppy).
    [Nature Communications]

    Full Article

    Metformin Inhibits MAPK Signaling and Rescues Pancreatic Aquaporin 7 Expression to Induce Insulin Secretion in Type 2 Diabetes Mellitus

    Researchers investigated the effects of different doses of metformin on AQP7 expression and explored the possible mechanism of its protective effects in the pancreatic islets.
    [Journal of Biological Chemistry]

    Full Article

    Silencing the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway Promotes Human β Cell Proliferation

    Investigators reported the development of a high-throughput RNAi screening approach to identify upstream pathways that regulated adult human β cell quiescence and demonstrated in a screen of the GPCRome that silencing G-protein coupled receptor 3 led to human pancreatic β cell proliferation.
    [Communications Biology]

    Full Article

    NEK2 Inhibition Triggers Anti-Pancreatic Cancer Immunity by Targeting PD-L1

    Researchers identified never in mitosis gene A-related kinase 2 (NEK2) as a prognostic factor in immunologically “hot” pancreatic cancer, involved in the onset and development of pancreatic tumors in an immune-dependent manner.
    [Nature Communications]

    Full Article

    Hypoxic Exosomal HIF-1α-Stabilizing circZNF91 Promotes Chemoresistance of Normoxic Pancreatic Cancer Cells via Enhancing Glycolysis

    Investigators reported a hypoxic exosomal circular RNA-mediated mechanism of conferred chemoresistance in pancreatic cancer cells.
    [Oncogene]

    Full Article

    ANGPTL4 Accelerates KRASG12D-Induced Acinar to Ductal Metaplasia and Pancreatic Carcinogenesis

    Scientists investigated the role of ANGPTL4 in KRASG12D-induced acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia formation, and pancreatic ductal adenocarcinoma maintenance.
    [Cancer Letters]

    Abstract

    TRIM15 Promotes the Invasion and Metastasis of Pancreatic Cancer Cells by Mediating APOA1 Ubiquitination and Degradation

    Researchers demonstrated that tripartite motif (TRIM) expression was elevated in pancreatic ductal adenocarcinomas tissues, and this elevated expression was associated with a poor prognosis.
    [Biochimica et Biophysica Acta-Molecular Basis of Disease]

    Abstract

    Gα15 in Early Onset of Pancreatic Ductal Adenocarcinoma

    Investigators described the distribution of GNA15 in adenocarcinoma from human pancreatic specimens and analyzed the mechanism driving abnormal expression and the consequences on signaling and clinical follow-up.
    [Scientific Reports]

    Full Article

    miRNA-7515 Suppresses Pancreatic Cancer Cell Proliferation, Migration and Invasion via Downregulating IGF-1 Expression

    Scientists determined the effects of miR‑7515 on pancreatic cancer cell proliferation, invasion and migration in vitro and in vivo, and investigated its underlying molecular mechanism using bioinformatics, double luciferase assay and western blotting.
    [Oncology Reports]

    Abstract

    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    100 YEARS OF INSULIN: A Brief History of Diabetes Genetics: Insights for Pancreatic Beta-Cell Development and Function

    The authors explore the timeline and history of gene discovery and how this has coincided with progress in the fields of genomics.
    [Journal of Endocrinology]

    Full Article

    INDUSTRY AND POLICY NEWS

    BYDUREON BCise (Exenatide Extended-Release) Approved in the US for the Treatment of Type 2 Diabetes in Pediatric Patients Ages Ten Years and Older

    AstraZeneca’s BYDUREON BCise, once-weekly injectable suspension has been approved in the US for the treatment of type 2 diabetes; to improve glycemic control in pediatric patients as an adjunct to diet and exercise.
    [AstraZeneca, Inc.]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Scientist – Type 2 Diabetes, Insulin Resistance and Fatty Liver

    Helmholtz Zentrum München – Tübingen, Germany

    Postdoctoral Researcher – Autoimmune Diabetes

    Columbia University Medical Center – New York City, New York, United States

    Assistant Research Scientist and Postdoctoral Research Associate – Diabetes

    Texas A&M University – College Station, Texas, United States

    Postdoctoral Fellow – Functional Genomics of Type II Diabetes

    Beth Israel Deaconess Medical Center – Cambridge, Massachusetts, United States

    Postdoctoral Fellowship – Cell Biology of Metabolic Regulation

    Harvard Joslin Diabetes Center – Boston, Massachusetts, United States

    > See All Jobs

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