 | | Vol. 12.30 – 3 August, 2021 |
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| Scientists employed an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-derived pancreatic ductal adenocarcinoma models.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 as phosphatases whose upregulation led to β-cell failure in diabetes.
[Cell Reports] |
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| Investigators made use of a clonal beta cell line (1.1B4) available from the European Collection of Authenticated Cell Cultures, which had been generated by the fusion of primary human beta-cells with a pancreatic ductal carcinoma cell, PANC-1.
[Scientific Reports] |
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| Researchers identified an important role for uridine diphosphate-glucose pyrophosphorylase 2 in the maintenance of pancreatic ductal adenocarcinoma growth in both in vitro and in vivo tumor models.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Based on a comprehensive investigation involving pancreatic cancer (PC) patient samples, murine models of PC progression, and loss and gain of function studies, investigators reported a previously undescribed critical role of microtubule-associated serine/threonine-protein kinase-like (MASTL) in promoting cancer malignancy and therapy resistance.
[Oncogene] |
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| Scientists identified APOL1 was abnormally elevated in human pancreatic cancer tissues compared with that in adjacent tissues and was associated with poor prognosis.
[Cell Death & Disease] |
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| The authors functionally studied candidate proteins using human normal and cancerous pancreatic ductal epithelial cell lines. 10-22 cell-derived pancreatic ductal adenocarcinoma (PDAC) displayed the molecular signature of clinical human PDAC.
[Molecular Cancer Research] |
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| Scientists introduced an intact human chromosome 3 into the human PK9 and murine LTPA pancreatic cancer cell lines using microcell-mediated chromosome transfer.
[Scientific Reports] |
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| Researchers conducted an effective prediction model to investigate the function of m6A RNA methylation modulators in pancreatic adenocarcinoma and estimated the potential association between m6A RNA methylation modulators and tumor microenvironment infiltration for optimization of treatment.
[BMC Cancer] |
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| The authors describe the molecular machinery of cell death, discuss the complexity and multifaceted nature of lethal signalling in pancreatic ductal adenocarcinoma cells, and highlight the challenges and opportunities for activating cell death pathways through precision oncology treatments.
[Nature Reviews Gastroenterology & Hepatology] |
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| Biocon Biologics Ltd. and Viatris Inc. announced that the US FDA has approved Semglee® as the first interchangeable biosimilar product under the 351(k) regulatory pathway.
[Biocon Biologics, Ltd.] |
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| October 27 – 29, 2021
Virtual |
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| Helmholtz Zentrum München – Tübingen, Germany |
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| Helmholtz Zentrum München – Tübingen, Germany |
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| Columbia University Medical Center – New York City, New York, United States |
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| Texas A&M University – College Station, Texas, United States |
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| Beth Israel Deaconess Medical Center – Cambridge, Massachusetts, United States |
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