 | | Vol. 12.31 – 10 August, 2021 |
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| Investigators detailed a six-stage planar differentiation methodology for generating human pluripotent stem cell–derived pancreatic β cells that secreted high amounts of insulin in response to glucose stimulation.
[Nature Protocols] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that proteomic analyses of pancreas tissue from non-obese diabetic mice suggested that FhHDM-1 activated the PI3K/Akt signaling pathway, which was associated with β-cell metabolism, survival and proliferation.
[Journal of Molecular Medicine] |
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| Researchers elucidated the effects of dipeptidyl peptidase-4 inhibitor and/or sodium-glucose co-transporter 2 inhibitor on β-cell mass and function and compared their effects between in an early and advanced phase of diabetes.
[Scientific Reports] |
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| A mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the TRAIL pathway was investigated in cultured cells and isolated mouse islets.
[Journal of Molecular Endocrinology] |
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| An inductively coupled plasma mass spectrometry (ICP-MS) and photothermal dual-readout platform was proposed for the ultrasensitive and point-of-care analysis of pancreatic cancer exosomes.
[Analytical Chemistry] |
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| Scientists chose a panel of PDAC cell lines with diverse sensitivity to cisplatin and gemcitabine. In PANC-1 chemoresistant cells, they found a low level of oxidative stress and high levels of Nrf2 and YAP protein expressions and their respective targets.
[Free Radical Biology and Medicine] |
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| Researchers studied the interaction between PDAC cells and pancreatic stellate cells in vitro and verified their finding with the survival data of patients with PDAC from the website of The Human Protein Atlas.
[Cancer Immunology Immunotherapy] |
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| Scientists showed that ANRIL was up-regulated while miR-181a was down-regulated in pancreatic cancer tissues and HMGB1 was highly expressed. Knockdown of ANRIL in pancreatic cancer repressed cellular proliferation, invasion, migration, and reduced chemotherapy resistance to gemcitabine.
[Aging] |
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| Researchers calculated IC50 of valproic acid -induced PANC-1 cells by combined analyses of proliferation and apoptosis, while assessing its effect on Wnt signaling pathway.
[Medical Oncology] |
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| Scientists discuss the state of the art of stem cell differentiation and islet engineering, reflect on current and future challenges in the area and highlight the potential for cell replacement therapies, disease modeling and drug development using these cells.
[Nature Reviews Drug Discovery] |
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| NexImmune, Inc. announced a collaboration with Yale University’s Department of Immunobiology. The collaboration will focus on the use of NexImmune’s direct injection, artificial antigen presenting cells with regards to the regulation of autoimmune diabetes (Type 1 diabetes). Dr. Kevan Herold, Deputy Director of Yale Center for Clinical Investigation and Co-Director of the Yale Diabetes Center will be the principal investigator.
[NexImmune, Inc.] |
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| September 7 – 11, 2022
Woods Hole, Massachusetts, United States |
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| Buck Institute for Research on Aging – Novato, California, United States |
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| Helmholtz Zentrum München – Tübingen, Germany |
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| Columbia University Medical Center – New York City, New York, United States |
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| Texas A&M University – College Station, Texas, United States |
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| Beth Israel Deaconess Medical Center – Cambridge, Massachusetts, United States |
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