Pancreatic Cell News Volume 12.32 | Aug 17 2021

    By
    Justin.choi
    -
    0
    33






    2021-08-17 | PACN 12.32


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.32 – 17 August, 2021
    TOP STORY

    Targeting Pin1 Renders Pancreatic Cancer Eradicable by Synergizing with Immunochemotherapy

    Researchers found that Pin1 was overexpressed both in cancer cells and cancer-associated fibroblasts and correlated with poor survival in pancreatic ductal adenocarcinoma patients.
    [Cell]

    AbstractGraphical Abstract

    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    The Hippo Kinase LATS2 Impairs Pancreatic β-Cell Survival in Diabetes through the mTORC1-Autophagy Axis

    Scientists reported that large-tumor suppressor 2, a core component of the Hippo signaling pathway, was activated under diabetic conditions and induced β-cell apoptosis and impaired function.
    [Nature Communications]

    Full Article

    Dynamin Deficiency Causes Insulin Secretion Failure and Hyperglycemia

    The authors investigated the process in mature mouse β cells by genetically deleting dynamin GTPase, the membrane fission machinery essential for clathrin-mediated endocytosis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Single Cell Transcriptomics Reveal Trans-Differentiation of Pancreatic Beta Cells Following Inactivation of the TFIID Subunit Taf4

    To address the function of the Taf4 subunit of general transcription factor TFIID in the regulation of insulin signaling, it was inactivated in adult murine pancreatic beta cells.
    [Cell Death & Disease]

    Full Article

    MiR-20b-5p Modulates Inflammation, Apoptosis and Angiogenesis in Severe Acute Pancreatitis through Autophagy by Targeting AKT3

    Cerulean and LPS was used to establish a rat model and an in vitro model of severe acute pancreatitis. qRT-PCR, western blot and IHC were determined to analyse the expression of mRNA and proteins. IL-1β, TNF-α and IL-6 levels were measured applying ELISA.
    [Autoimmunity]

    Abstract

    GOT1 Inhibition Promotes Pancreatic Cancer Cell Death by Ferroptosis

    Researchers identified metabolic dependencies following cytosolic aspartate aminotransaminase (GOT1) driven pathway in pancreatic cancer and provided additional insight into regulation of redox metabolism.
    [Nature Communications]

    Full Article

    Targeting of Pancreatic Cancer Cells and Stromal Cells Using Engineered Oncolytic Salmonella typhimurium

    Scientists used a targeted cancer therapy approach based on attenuated S. typhimurium engineered to express cytolysin A to target cancer stromal cells and cancer cells, and treat pancreatic cancer in mice.
    [Molecular Therapy]

    AbstractGraphical Abstract

    PRR11 Unveiled as a Top Candidate Biomarker within the RBM3-Regulated Transcriptome in Pancreatic Cancer

    Investigators unearthed RBM3-regulated genes and proteins in pancreatic cancer cells in vitro, and to examine their expression and prognostic significance in human tumors.
    [Journal of Pathology Clinical Research]

    Full Article

    EPS8 Supports Pancreatic Cancer Growth by Inhibiting BMI1 Mediated Proteasomal Degradation of ALDH7A1

    Researchers explored the interplay between epidermal growth factor receptor kinase substrate 8 and aldehyde dehydrogenase 7 family member A1 (ALDH7A1) in pancreatic ductal adenocarcinoma (PADC) cells. PADC cell lines MIA PaCa-2 and AsPANC-1 were used for in vitro and in vivo studies.
    [Experimental Cell Research]

    Abstract

    Dickkopf-Related Protein 3 Alters Aerobic Glycolysis in Pancreatic Cancer BxPC-3 Cells, Promoting CD4+ T-cell Activation and Function

    The BxPC-3-DKK3 cell line was constructed, and peripheral blood mononuclear cell was prepared. After isolation the CD4+ T cells, the lactic acid, glucose uptake ability, cellular viability, proliferation, apoptosis, and markers were detected by PCR and western blot, and the concentrations of multiple cytokines were determined using the ELISA method.
    [European Journal of Medical Research]

    Abstract

    Five tips for returning to the lab after time off
    REVIEWS

    Process Parameter Development for the Scaled Generation of Stem Cell-Derived Pancreatic Endocrine Cells

    Scientists discussed the potential of both stem cell-derived pancreatic progenitors and more matured insulin-producing cells to treat diabetes.
    [Stem Cells Translational Medicine]

    Full Article

    One Hundred Years of Insulin Therapy

    At the time of its first clinical application 100 years ago, insulin was presented as the cure for people with diabetes mellitus. That transpired to be an overstatement, yet insulin has proven to be the lifesaver for people with type 1 diabetes mellitus and an essential therapy for many with type 2 diabetes mellitus or other forms of diabetes mellitus.
    [Nature Reviews Endocrinology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Insulet Announces FDA Clearance of Lyumjev® Rapid-Acting Insulin for Use with Omnipod® Products in the United States

    Insulet Corporation, Inc. announced FDA clearance for use of Eli Lilly and Company’s Lyumjev® 100 units/mL with Insulet’s Omnipod® Insulin Management System and Omnipod DASH® Insulin Management System.
    [Insulet Corporation, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Bioprinting for Pancreas Biofabrication

    University Medical Center Utrecht – Utrecht, Netherlands

    Postdoctoral Researcher – Diabetes, Obesity and Neurodegeneration

    Buck Institute for Research on Aging – Novato, California, United States

    Scientist – Type 2 Diabetes, Insulin Resistance and Fatty Liver

    Helmholtz Zentrum München – Tübingen, Germany

    Postdoctoral Researcher – Autoimmune Diabetes

    Columbia University Medical Center – New York City, New York, United States

    Assistant Research Scientist and Postdoctoral Research Associate – Diabetes

    Texas A&M University – College Station, Texas, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pancreatic Cell News Twitter