 | | Vol. 12.34 – 31 August, 2021 |
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| The authors identified a redox homeostasis network containing the iron-sulfur cluster enzyme, NFS1. Depletion of NFS1 or blocking cyst(e)ine availability by inhibiting xCT, while targeting carbonic anhydrase IX, enhanced ferroptosis and significantly inhibited tumor growth.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used a well-controlled human induced pluripotent stem cell (iPSC) pancreatic differentiation model to elucidate the molecular mechanisms underlying HNF1B-associated diabetes.
[Stem Cell Reports] |
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| Scientists investigated the intracellular signaling pathway following stimulation of Cav1.2 Ca2+ channels and addressed the function of the transcription factor activator protein-1 in pancreatic β-cells of transgenic mice.
[Biochemical Pharmacology] |
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| Researchers identified key genes and pathways in the development of pancreatic cancer and provide targets for the treatment of pancreatic cancer.
[Journal of Translational Medicine] |
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| Scientists demonstrated that the prototypical Smac mimetic BV6 cooperated with the stimulator of interferon genes ligand 2′,3′-cyclic guanosine monophosphate–adenosine monophosphate to trigger necroptosis in apoptosis-deficient pancreatic cancer cells
[Cell Death & Disease] |
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| Researchers showed that when the GLP-1R and GIPR receptors were co-expressed in HEK 293T cells with comparable receptor ratio to pancreatic cancer cells, glucose-dependent insulinotropic polypeptide (GIP) predominately induced cAMP accumulation while Glucagon-like peptide-1 (GLP-1) was biased towards β-arrestin 2 recruitment.
[Acta Pharmacologica Sinica] |
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| The effects of gene therapy using small interfering RNA and short hairpin RNA for acid ceramidase inhibition with its mechanisms for pancreatic cancer were investigated.
[Cancer Science] |
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| The expression of antisense of KTN1 (KTN1-AS1) in tissues and cells was detected by qRT-PCR, and the relationship between KTN1-AS1 and clinicopathological data of patients with pancreatic cancer was analyzed.
[Aging-Us] |
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| The authors investigated the mechanism by which lncRNA LINC00261 affected the biological functions of cancer stem cells during the progression of pancreatic cancer.
[Cell Death Discovery] |
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| Investigators reported that Chibby(Cby)1-knockout (KO) mice developed severe exocrine pancreatic atrophy with dilated ducts during early postnatal development. A significant reduction in the number and length of cilia was observed in Cby1-KO pancreta.
[Scientific Reports] |
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| Scientists discuss the main cellular and molecular mechanisms underlying the involvement of the extracellular matrix, immune cells, and metabolic remodeling in the induction of gemcitabine resistance.
[Cancer Letters] |
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| Recent studies of the human microbiome have offered new insights into how the microbiome can impact cancer development and treatment. Specifically, in PDAC, the microbiota has been shown to modulate PDAC risk, contribute to tumorigenesis, impact the tumor microenvironment, and alter treatment response.
[Cancer and Metastasis Reviews] |
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| Pancreatic cancer (PC) remains an incurable disease with few treatment options. Recently, promising targets have been identified and novel therapeutic drugs are currently under development in KRAS wild-type PC.
[Critical Reviews in Oncology/Hematology] |
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| Adhera Therapeutics, Inc. announced that the company has executed an exclusive license agreement with Melior Pharmaceuticals I, Inc. defining the terms and conditions for which Adhera will license MLR-1023 from Melior Pharma 1 for the purpose of developing a novel therapeutic for Type 1 diabetes.
[Adhera Therapeutics, Inc.] |
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| Can dendritic cells found in the skin be an important piece of the puzzle of enabling stem cell transplants for diabetes? Michael Sefton, a renowned University of Toronto (U of T) tissue engineer, is confident enough about the possibility that – with support from the type 1 diabetes non-profit JDRF – he is about to launch a major new chapter in his research.
[University of Torontot] |
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| October 19, 2021
London, England, United Kingdom |
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| | European Centre Study Diabetes – Strasbourg, France |
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| National University of Ireland Galway – Galway, Ireland |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| Buck Institute for Research on Aging – Novato, California, United States |
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| Helmholtz Zentrum München – Tübingen, Germany |
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