 | | Vol. 12.35 – 7 September, 2021 |
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| Lineage tracing using the Neurogenin3 (Ngn3)-CreERT line identified ductal cells expressing the endocrine master transcription factor Ngn3 that were positive for the δ cell marker somatostatin and occasionally co-expressed insulin.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Scientists enhanced subcutaneous engraftment by employing a unique vascularization strategy based on ready-made microvessels isolated from the adipose tissue.
[Cell Stem Cell] |
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| Using massively parallel reporter assays, the authors tested the cis-regulatory effects of single nucleotide polymorphisms associated with type 2 diabetes (T2D) and altered in vivo islet chromatin accessibility in MIN6 β cells under steady state and pathophysiologic endoplasmic reticulum stress conditions.
[Nature Communications] |
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| Researchers investigated the role of puerarin in endoplasmic reticulum stress-associated apoptosis and explored its underlying mechanism in the mouse insulinoma cell line.
[American Journal of Chinese Medicine] |
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| Investigators developed a size switchable nanosystem based on PEG–PLGA nanospheres encapsulated within liposomes for the combined delivery of vactosertib, a TGF-β1 receptor kinase inhibitor, and the cytotoxic drug paclitaxel.
[ACS Nano] |
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| Kaplan–Meier plotter was used to analyze the prognostic significance of each of the all-known receptor tyrosine kinases to date in immune “hot” and “cold” pancreatic cancers.
[Journal of Experimental & Clinical Cancer Research] |
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| Long non-coding RNA microarray was adopted to analyze the differential expression of lncRNAs in pancreatic cancer tissues and that in normal peritumoral tissues.
[Cell Death & Disease] |
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| In a panel of 3D, extracellular matrix based PDAC cell cultures, β1 integrin was inhibited by antibodies or siRNA-mediated knockdown. Together with X-ray irradiation and specific chemotherapies, scientists determined 3D colony formation capacity in therapy-naïve and radioresistant PDAC cultures.
[International Journal of Radiation Oncology Biology Physics] |
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| Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3.
[Cancer Gene Therapy] |
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| Ectopic expression and knockdown experiments were conducted in pancreatic cancer (PC) cells, PC cells-derived EVs, or mouse xenograft model of PC.
[International Immunopharmacology] |
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| RT-qPCR was performed to analyze the expression of repulsive guidance molecule BMP co-receptor b antisense RNA 1 (RGMB-AS1) expression. Scientists determined RGMB-AS1 influence on prostate cancer cell malignant behaviors via functional assays.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| The clinical relevance of cancer-associated fibroblasts is summarized with an emphasis on their value as prognosis factors and therapeutic targets.
[Nature Reviews Clinical Oncology] |
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| β cells in the hyperglycemic environment of diabetes have marked changes in phenotype and function that are largely reversible if glucose levels can be returned to normal. A leading hypothesis is that these changes are caused by the elevated glucose levels leading to the concept of glucose toxicity.
[Metabolism-Clinical and Experimental] |
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| Inversago Pharma, Inc. announced that following the receipt of a No Objection Letter from Health Canada on July 29, 2021, it has dosed the first volunteers with INV-202 in its first-in-human Phase I clinical trial, which will evaluate the safety, tolerability and pharmacokinetics of this compound.
[Inversago Pharma, Inc.] |
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| Fractyl Health, Inc. announced the activation of the tenth clinical site in the company’s pivotal REVITA-T2Di trial taking place across the US and Europe.
[Fractyl Health, Inc.] |
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| October 19 – 20, 2021
Virtual |
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| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | European Centre Study Diabetes – Strasbourg, France |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
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