Pancreatic Cell News Volume 12.36 | Sep 14 2021

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    2021-09-14 | PACN 12.35


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.36 – 14 September, 2021
    TOP STORY

    A Microenvironment-Inspired Synthetic Three-Dimensional Model for Pancreatic Ductal Adenocarcinoma Organoids

    Experimental in vitro models that capture pathophysiological characteristics of human tumors are essential for basic and translational cancer biology. Researchers described a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.
    [Nature Materials]

    Abstract

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    A Therapeutic Convection–Enhanced Macroencapsulation Device for Enhancing β Cell Viability and Insulin Secretion

    The authors showed that convective transport improved nutrient delivery throughout the device and afforded a 3D capsule geometry that encapsulated 9.7-fold-more cells than conventional macroencapsulation devices.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    3D Imaging of Human Organs with Micrometer Resolution – Applied to the Endocrine Pancreas

    Scientists demonstrated the utility of the approach by providing volumetric data and three dimensional distribution of hundreds of thousands of islets of Langerhans within the human pancreas.
    [Communications Biology]

    Full Article

    Single-Cell Heterogeneity Analysis and CRISPR Screens in MIN6 Cell Line Reveal Transcriptional Regulators of Insulin

    Researchers performed pooled CRISPR delivery with single-cell transcriptome analysis on the MIN6 cell line, a pancreatic β-cell line. They presented the single-cell RNA sequencing readout and demonstrated that the MIN6 cell line might develop genetic heterogeneity with increasing passage number based on GO and KEGG pathway analysis.
    [Cell Cycle]

    Abstract

    MicroRNA-532-5p Regulates Oxidative Stress and Insulin Secretion Damage in High Glucose-Induced Pancreatic β Cells by Downregulating the Expression Levels of CCND1

    Scientists investigated the specific mechanism underlying the effects of miR‑532‑5p on diabetes. Cell viability was determined using an MTT assay. The expression levels of miR‑532‑5P, cyclin D1, Insulin1 and Insulin2 were detected using reverse transcription‑quantitative PCR.
    [Molecular Medicine Reports]

    Abstract

    MAP4K4 Promotes Pancreatic Tumorigenesis via Phosphorylation and Activation of Mixed Lineage Kinase 3

    Researchers identified MLK3 as a direct downstream target of MAP4K4. The MAP4K4 and MLK3 associated with each other, and MAP4K4 phosphorylated MLK3 on Thr738 and increased MLK3 kinase activity and downstream signaling.
    [Oncogene]

    Full Article

    Targeting Tumor-Stromal IL-6/STAT3 Signaling through IL-1 Receptor Inhibition in Pancreatic Cancer

    Investigators showed that IL-1α was overexpressed in both murine and human pancreatic ductal adenocarcinomatumors and engaged with its cognate receptor IL-1R1 which was strongly expressed on stromal cells.
    [Molecular Cancer Therapeutics]

    Abstract

    Hypoxia Increases KIAA1199/CEMIP Expression and Enhances Cell Migration in Pancreatic Cancer

    Using quantitative real-time RT-PCR and western blot analysis, scientists analyzed the changes in the expression of HA-synthesizing enzymesand hyaluronan HA-degrading enzymes in pancreatic ductal adenocarcinoma cell lines under hypoxic conditions.
    [Scientific Reports]

    Full Article

    Exosome-Mediated lncRNA SNHG11 Regulates Angiogenesis in Pancreatic Carcinoma through miR-324-3p/VEGFA Axis

    LncRNAs play significant roles in the occurrence and development of various cancers. LncRNA SNHG11 has been found to display high expression in serum of pancreatic cancer (PC) patients, which implied that dysregulated SNHG11 might be related to development of PC.
    [Cell Biology International]

    Abstract

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Autophagy in Metabolic Disease and Aging

    Scientists summarize the role of autophagy in the pathogenesis of metabolic diseases associated with or occurring in the context of aging, including insulin resistance, type 2 diabetes mellitus and sarcopenic obesity, and describe its potential as a therapeutic target.
    [Nature Reviews Endocrinology]

    Abstract

    Current Understanding of Ferroptosis in the Progression and Treatment of Pancreatic Cancer

    The authors review the current understanding of the mechanism of ferroptosis and ferroptosis-related treatment in pancreatic cancer.
    [Cancer Cell International]

    Full Article

    INDUSTRY AND POLICY NEWS

    Novocure Announces Clinical Trial Collaboration with Roche to Evaluate Tumor Treating Fields as Part of a Novel Combination for the First-Line Treatment of Metastatic Pancreatic Cancer

    Novocure announced that it has entered into a clinical trial collaboration agreement with Roche, to develop Tumor Treating Fields together with Roche’s anti-PD-L1 therapy, atezolizumab, in metastatic pancreatic ductal adenocarcinoma.
    [Novocure, GmbH]

    Press Release

    FEATURED EVENT

    The NYSCF Conference – New York Stem Cell Foundation

    October 19 – 20, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Pancreatic Cancer Heterogeneity

    LIRCCS Candiolo Cancer Institute – Turin, Italy

    Postdoctoral Positions – Organ Cross-Talk and Metabolic Disorders

    European Centre Study Diabetes – Strasbourg, France

    Postdoctoral Fellow – Bioprinting for Pancreas Biofabrication

    University Medical Center Utrecht – Utrecht, Netherlands

    Postdoctoral Researcher – Diabetes, Obesity and Neurodegeneration

    Buck Institute for Research on Aging – Novato, California, United States

    Scientist – Type 2 Diabetes, Insulin Resistance and Fatty Liver

    Helmholtz Zentrum München – Tübingen, Germany

    > See All Jobs

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