Pancreatic Cell News Volume 12.38 | 2021-09-28

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    2021-09-28 | PACN 12.38


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.38 – 28 September, 2021
    TOP STORY

    A 584 BP Deletion in CTRB2 Inhibits Chymotrypsin B2 Activity and Secretion and Confers Risk of Pancreatic Cancer

    Scientists proposed that intracellular accumulation of a nonfunctional chymotrypsinogen B2 protein led to endoplasmic reticulum stress and pancreatic inflammation, which might explain the increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles.
    [American Journal of Human Genetics]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Vitamin D Decreases Pancreatic Iron Overload in Type II Diabetes through the NF-κB-DMT1 Pathway

    The authors explored the underlying mechanisms of type II diabetes prevention by vitamin D, concentrating on pancreatic iron deposition reported recently.
    [Journal of Nutritional Biochemistry]

    Abstract

    Bioengineered 3D Models of Human Pancreatic Cancer Recapitulate In Vivo Tumor Biology

    Researchers developed a comprehensive and highly tuneable ex vivo model of pancreatic ductal adenocarcinoma based on the 3D co-assembly of peptide amphiphiles with custom extracellular matrix components.
    [Nature Communications]

    Full Article

    Tetrahedral Framework Nucleic Acid Delivered RNA Therapeutics Significantly Attenuate Pancreatic Cancer Progression via Inhibition of CTR1-Dependent Copper Absorption

    Researchers utilized tetrahedral framework nucleic acids as vehicles to overcome the biological barriers for delivering small molecular RNAs and efficiently transferred two kinds of copper transporter (CTR1) mRNA-targeted RNA therapeutics, siCTR1 or miR-124, into PANC-1 cells.
    [ACS Applied Materials & interfaces]

    AbstractGraphical Abstract

    Hyaluronic Acid Nanoparticles Encapsulated microRNA-125b Repolarizes Tumor-Associated Macrophages in Pancreatic Cancer

    Investigators investigated a novel strategy to target tumor-associated macrophages and reprogrammed them to an antitumor phenotype in pancreatic adenocarcinoma.
    [Nanomedicine]

    AbstractGraphical Abstract

    Long Non-Coding RNA NORAD Promotes Pancreatic Cancer Stem Cell Proliferation and Self-Renewal by Blocking microRNA-202-5p-Mediated ANP32E Inhibition

    Expression of long noncoding RNAs NORAD, miR-202-5p and ANP32E in pancreatic cancer tissues and cell lines was quantified after RNA isolation. Dual-luciferase reporter assay, RNA pull-down and RIP assays were performed to verify the interactions among NORAD, miR-202-5p and ANP32E.
    [Journal of Translational Medicine]

    Abstract

    Long Non-Coding RNA SOX2OT Promotes Pancreatic Cancer Cell Migration and Invasion through Destabilizing FUS Protein via Ubiquitination

    Scientists performed RNA pull-down, cycloheximide-chase, and ubiquitination assays to determine the effect of SOX2OT on FUS ubiquitination, and explored the specific regulatory mechanism of SOX2OT–FUS axis in pancreatic cancer cell migration, invasion, in vivo tumor growth, and metastasis through RNA sequencing.
    [Cell Death Discovery]

    Full Article

    Long Non-Coding RNA ZFAS1 Promotes Pancreatic Cancer Proliferation and Metastasis by Sponging miR-497-5p to Regulate HMGA2 Expression

    The authors identified the role and molecular mechanisms of ZFAS1 in pancreatic cancer. The expression of ZFAS1, miR-497-5p and HMGA2 in pancreatic cancer tissues was detected by qRT-PCR.
    [Cell Death Discovery]

    Full Article

    HOXD9-Induced SCNN1A Upregulation Promotes Pancreatic Cancer Cell Proliferation, Migration and Predicts Prognosis by Regulating Epithelial-Mesenchymal Transformation

    Sodium channel epithelial 1α subunit (SCNN1A) serves an important role in tumor progression. Scientists explored the role of homeobox D9 (HOXD9) and SCNN1A in the progression of pancreatic cancer.
    [Molecular Medicine Reports]

    Abstract

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    REVIEWS

    Pancreatic β-Cell Development and Regeneration

    The authors describe the development and function of β-cells the emerging concept of heterogeneity within insulin-producing cells, and the potential of other cell types to assume β-cell functionality via transdifferentiation.
    [Cold Spring Harbor Perspectives in Biology]

    Full Article

    ACE2 Function in Pancreatic Islet: Implications for Relationship between SARS-CoV-2 and Diabetes

    Given the ability of SARS-COV-2 to infect human pluripotent stem cell-derived pancreatic cells in vitro and the presence of SARS-CoV-2 in pancreatic samples from COVID-19 patients strongly hints that SARS-CoV-2 can invade the pancreas and directly cause pancreatic injury and diabetes.
    [Acta Physiologica]

    Full Article

    Diversity of Pathophysiology in Type 2 Diabetes Revealed by Islet Pathology

    Recent research has suggested that transdifferentiation and dedifferentiation are involved in the decrease in β-cell volume and that it may change dynamically depending on the glucose metabolic state.
    [Journal of Diabetes investigation]

    Abstract

    INDUSTRY AND POLICY NEWS

    T.H.A.C Announces the Acquisition of an International Patent on Its Drug Candidate ALF-5755 for the Early Treatment of Type 2 Diabetes Mellitus and Relative to the Gut Microbiota Composition

    T.H.A.C SA, announces the acquisition of an international patent submitted by INSERM, Hospitals of Paris, INRA, and the University of Paris.
    [T.H.A.C SA (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Cell-NCI Symposium: Beyond Cancer Genomics Toward Precision Oncology

    October 4 – 6, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Bioinformatics

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Associate – Type II Diabetes

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Pancreatic Cancer Heterogeneity

    LIRCCS Candiolo Cancer Institute – Turin, Italy

    Postdoctoral Positions – Organ Cross-Talk and Metabolic Disorders

    European Centre Study Diabetes – Strasbourg, France

    Postdoctoral Fellow – Bioprinting for Pancreas Biofabrication

    University Medical Center Utrecht – Utrecht, Netherlands

    > See All Jobs

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