Pancreatic Cell News Volume 12.39 | Oct 05 2021

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    2021-10-05 | PACN 12.39


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.39 – 5 October, 2021
    TOP STORY

    Intravital Imaging Technology Guides FAK-Mediated Priming in Pancreatic Cancer Precision Medicine according to Merlin Status

    Scientists visualized transient manipulation of focal adhesion kinase, which integrated bidirectional cell-environment signaling, using intravital fluorescence lifetime imaging microscopy of the FAK-based Förster resonance energy transfer biosensor in mouse and patient-derived pancreatic ductal adenocarcinoma models.
    [Science Advances]

    Full Article

    Resources for Your T Cell Therapy Research
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    Detecting Insulitis in Type 1 Diabetes with Ultrasound Phase-Change Contrast Agents

    Researchers presented ultrasound imaging of nanodroplet (ND) contrast-agent accumulation within the islet. ND accumulation was dependent on immune infiltration; therefore, it tracked presymptomatic type I diabetes development and progression to diabetes
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    1α, 25-(OH)2 Vitamin D3 Prevents Insulin Resistance and Regulates Coordinated Exocytosis and Insulin Secretion

    The authors investigated the short-term effect of 1α,25(OH)2 vitamin D3 and cholecalciferol on the glycemia and insulin sensitivity of control and dexamethasone-induced insulin-resistance in rats.
    [Journal of Nutritional Biochemistry]

    Abstract

    ATP Synthase Inhibitory Factor Subunit 1 Regulates Islet β-Cell Function via Repression of Mitochondrial Homeostasis

    ATP synthase inhibitory factor subunit 1 (IF1) is a mitochondrial protein interacting with ATP synthase to inhibit its enzyme activity. Scientists investigated islets freshly isolated from mouse lines with global inhibitory factor subunit 1 knockout and overexpression.
    [Laboratory Investigation]

    Abstract

    A20 Controls Expression of Beta-Cell Regulatory Genes and Transcription Factors

    Scientists investigated the mechanisms underlying the protective role of A20 in the pancreatic beta-cell. They demonstrated a role for A20 in controling beta-cell integrity and survival, which likely resulted from the regulation of inflammatory signaling
    [Journal of Molecular Endocrinology]

    Abstract

    Single-Cell Analysis of Patient-Derived PDAC Organoids Reveals Cell State Heterogeneity and a Conserved Developmental Hierarchy

    Researchers derived pancreatic ductal adenocarcinoma organoids from 18 primary tumors and two matched liver metastases, and showed that ‘classical’ and ‘basal-like’ cells coexist in individual organoids.
    [Nature Communications]

    Full Article

    Multifunctional Thiosemicarbazones Targeting Sigma Receptors: In Vitro and In Vivo Antitumor Activities in Pancreatic Cancer Models

    Scientists developed a novel sigma-2 receptor targeting thiosemicarbazone that incorporated a moiety associated with lysosome destabilization and ROS increase in order to design more efficient antitumor agent.
    [Cellular Oncology]

    Full Article

    RUNX2 and LAMC2: Promising Pancreatic Cancer Biomarkers Identified by an Integrative Data Mining of Pancreatic Adenocarcinoma Tissues

    Pancreatic carcinoma (PC) is a severe disease associated with high mortality. To identify biomarkers for early diagnosis and therapy, three mRNA microarray datasets and two miRNA datasets were selected, and combinative analysis was performed by GEO2R.
    [Aging]

    Full Article

    Cholesterol Biosynthesis Inhibitor RO 48–8071 Inhibits Pancreatic Ductal Adenocarcinoma Cell Viability by Deactivating the JNK and ERK/MAPK Signaling Pathway

    RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.
    [Molecular Medicine Reports]

    Abstract

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    REVIEWS

    The Molecular Mechanism of Vgf in Appetite, Lipids, and Insulin Regulation

    The mechanisms of obesity and diabetes and the crosstalk between these diseases are still ambiguous. The authors clarified and explained the role of VGF peptides in the brain, pancreas, and adipose tissue in the development of obesity.
    [Pharmacological Research]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Precigen ActoBio Announces Additional Positive Interim Data from Phase Ib/IIa Study of AG019 ActoBiotics™, a Novel Therapy Designed to Address the Underlying Cause of Type 1 Diabetes

    Precigen ActoBio, announced additional positive interim data from the ongoing Phase Ib/IIa clinical study investigating AG019 ActoBiotics™ for the treatment of recent-onset type 1 diabetes.
    [Precigen ActoBio]

    Press Release

    FEATURED EVENT

    Biological Assemblies: Phase Transitions

    November 1 – 3, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Neurobiology of Obesity and Diabetes

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Bioinformatics

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Functional Genomics of Type II Diabetes

    Beth Israel Deaconess Medical Center – Cambridge, Massachusetts, United States

    Postdoctoral Fellow – Pancreatic Cancer Heterogeneity

    LIRCCS Candiolo Cancer Institute – Turin, Italy

    Postdoctoral Positions – Organ Cross-Talk and Metabolic Disorders

    European Centre Study Diabetes – Strasbourg, France

    > See All Jobs

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