 | | Vol. 12.40 – 12 October, 2021 |
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| Investigators deconvoluted the human pancreatic tumor microenvironment through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating over 500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems.
[Cell Reports] |
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| MAFAS64F production in male human β cells accelerated cellular senescence and increase senescence-associated secretory proteins compared to cells expressing MAFAWT.
[Cell Reports] |
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| Transcriptomic analysis of 84 pancreatic neuroendocrine neoplasm specimens, drawn from two cohorts, was substantiated with proteomic profiling and identifies four subgroups: Proliferative, PDX1-high, Alpha cell-like and Stromal/Mesenchymal.
[Cell Reports] |
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| FLVCR1-AS1 expression levels in 77 pancreatic cancer tissues and matched non-tumor tissues were analyzed by qRT-PCR.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.
[Cancer Science] |
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| Researchers observed both common and distinct patterns of glycosylation in pancreatic cancer across species. Common alterations included increased levels of α-2,3- and α-2,6-sialic acids, bisecting GlcNAc and poly-LacNAc.
[Molecular & Cellular Proteomics] |
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| Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.
[Aging-Us] |
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| Researchers focused upon the effect of propofol on pancreatic cancer cells and the mechanism by which propofol reduced A disintegrin and metalloproteinase 8 (ADAM8) expression.
[Oncology Reports] |
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| Adopting a 3D rotary cell culture system, scienists co-cultured several PDAC cell lines and MIN6 islet β cells.
[Pancreas] |
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| Designing materials to decrease antigen escape, improve cell viability, and increase material compatibility are all approaches that can decrease the local release of antigen and danger signals into the implant microenvironment.
[Acta Biomaterialia] |
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| Investigators celebrate the 100th anniversary of the discovery of insulin and consolidate the key milestones and advances in the development of recombinant human insulin.
[Med] |
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| Hansoh Pharmaceutical Group Co, Ltd and OliX Pharmaceuticals, Inc. announced a licensing and collaboration agreement to discover, develop and commercialize siRNA therapeutics in key targeted indications in Greater China.
[Hansoh Pharmaceutical Group Co, Ltd (GlobeNewswire, Inc.)] |
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| vTv Therapeutics, Inc. a clinical-stage biopharmaceutical company focused on the development of orally administered treatments for type 1 diabetes and psoriasis, announced positive results of a mechanistic study of TTP399 in patients with type 1 diabetes.
[vTv Therapeutics, Inc.] |
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| November 8 – 10, 2021
Virtual |
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| | Harvard Joslin Diabetes Center – Duarte, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| LIRCCS Candiolo Cancer Institute – Turin, Italy |
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| | European Centre Study Diabetes – Strasbourg, France |
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