Pancreatic Cell News Volume 12.41 | Oct 19 2021

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    2021-10-19 | PACN 12.41


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.41 – 19 October, 2021
    TOP STORY

    Epithelial Memory of Inflammation Limits Tissue Damage While Promoting Pancreatic Tumorigenesis

    By investigating the effects of inflammation on normal pancreatic epithelial cells in different mouse models, scientists discovered that long after the complete resolution, a transient inflammatory event primed pancreatic epithelial cells to cooperate with oncogenic Kras to induce pancreatic tumors.
    [Science]

    AbstractGraphical Abstract

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    The Healthy Exocrine Pancreas Contains Preproinsulin-Specific CD8 T Cells That Attack Islets in Type 1 Diabetes

    The authors quantified preproinsulin-specific CD8+ T cells within different areas of the human pancreas from nondiabetic controls, autoantibody-positive donors, and donors with type 1 diabetes to investigate their role in diabetes development.
    [Science Advances]

    Abstract

    Human Islet T Cells Are Highly Reactive to Preproinsulin in Type 1 Diabetes

    Scientists comprehensively examined preproinsulin specificity of CD8 T cells obtained from pancreatic islets of organ donors with and without type 1 diabetes (T1D) and identified epitopes throughout the entire preproinsulin protein and defective ribosomal products derived from preproinsulin messenger RNA.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Copine 3 “CPNE3” Is a Novel Regulator for Insulin Secretion and Glucose Uptake in Pancreatic β-Cells

    Copine 3 (CPNE3) is a calcium-dependent phospholipid-binding protein that has been found to play an essential role in cancer progression and stages. RNA sequencing and microarray data revealed that CPNE3 was highly expressed in human islets compared to other CPNE genes.
    [Scientific Reports]

    Full Article

    Identification of Protease Serine S1 Family Member 53 as a Mitochondrial Protein in Murine Islet Beta Cells

    Scientists identified genes that were specifically expressed in pancreatic islet β-cells. Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived from murine MIN6 β-cells, through homology comparisons using the GenBank database.
    [Islets]

    Abstract

    Marker-Free Lineage Tracing Reveals an Environment-Instructed Clonogenic Hierarchy in Pancreatic Cancer

    Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Loss of the Wild-Type KRAS Allele Promotes Pancreatic Cancer Progression through Functional Activation of YAP1

    Investigators showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.
    [Oncogene]

    Abstract

    Transcriptome and Proteome Analysis of the Antitumor Activity of Maslinic Acid against Pancreatic Cancer Cells

    Maslinic acid (MA) is a triterpenoid compound of natural abundance in olive plants possessing numerous biological activities. Researchers explored the anti-tumor activity of MA on human pancreatic cancer cells and the potential underlying molecular mechanism.
    [Aging]

    Full Article

    MK8722, an AMPK Activator, Inhibiting Carcinoma Proliferation, Invasion and Migration in Human Pancreatic Cancer Cells

    MK8722 is a potent and systemic pan-AMPK activator. It is an effective, direct, allosteric activator of AMPK complex in many mammals. Scientists investigated the anti-pancreatic cancer cells effects of MK8722 on two different human pancreatic cancer cell lines.
    [Biomedicine & Pharmacotherapy]

    Full Article

    How is drug screening being revolutionized for cystic fibrosis? With organoids. Watch Sylvia Boj's webinar.
    REVIEWS

    The Physiological Role of β-Cell Heterogeneity in Pancreatic Islet Function

    The focus of this review is the description of how endocrine cell heterogeneity affects the regulation of hormone secretion within the islets of Langerhans.
    [Nature Reviews Endocrinology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Better Therapeutics Enrolls First Patient in Real-World Evidence Study with Catalyst Health Network Evaluating BT-001, a Prescription Digital Therapeutic for Type 2 Diabetes

    Better Therapeutics, Inc. announced the first patient has been enrolled in a real-world evidence study to evaluate the long-term effectiveness and healthcare utilization changes associated with the use of BT-001 for the treatment of type 2 diabetes.
    [Better Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    FSSCR French Society for Stem Cell Research

    November 9 – 10, 2021
    Montpellier, France

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    JOB OPPORTUNITIES

    Postdoctoral position – Pancreatic Adenocarcinoma

    University of California Los Angeles – Los Angeles, California, United States

    Postdoctoral Fellowship – Obesity and Diabetes

    Harvard Joslin Diabetes Center – Duarte, California, United States

    Postdoctoral Associate – Neurobiology of Obesity and Diabetes

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Bioinformatics

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Pancreatic Cancer Heterogeneity

    LIRCCS Candiolo Cancer Institute – Turin, Italy

    > See All Jobs

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