Pancreatic Cell News Volume 12.42 | Oct 26 2021

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    2021-10-26 | PACN 12.42


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.42 – 26 October, 2021
    TOP STORY

    Enzyme-Activatable Aggregation-Induced Emission Probe: Intraoperative-Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E

    Investigators developed an enzyme activatied aggregation-induced emission probe QM-HSP-CPP for high-contrast fluorescence diagnosis of pancreatic cancer by monitoring specific overexpressed enzyme cathepsin E.
    [Advanced Materials]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Human Skeletal Muscle CD90+ Fibro-Adipogenic Progenitors Are Associated with Muscle Degeneration in Type 2 Diabetic Patients

    The authors showed that skeletal muscle of type 2 diabetes mellitus patients exhibited degenerative remodeling of the ECM that was associated with a selective increase of a subpopulation of fibro-adipogenic progenitors (FAPs) marked by expression of THY1 (CD90)—the FAPCD90+.
    [Cell Metabolism]

    AbstractGraphical Abstract

    Comparative Analysis of Reconstructed Architectures from Mice and Human Islets

    Aiming to contribute to a better understanding of the relationship between structural and functional properties of pancreatic islets, researchers reconstructed human and mice islets in order to perform a structural comparison based on both morphologic and network-derived metrics.
    [Islets]

    Abstract

    Reduction in O-Glycome Induces Differentially Glycosylated CD44 to Promote Stemness and Metastasis in Pancreatic Cancer

    Using several in vitro and in vivo models lacking C1GALT1 expression, investigators identified the role of aberrant O-glycosylation in stemness properties and aggressive pancreatic cancer metastasis.
    [Oncogene]

    Abstract

    Semiconducting Polymer Nano-Radiopharmaceutical for Combined Radio-Photothermal Therapy of Pancreatic Tumor

    Researchers reported a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope 177Lu for combined radio- and photothermal therapy of pancreatic tumor.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Lnc-PFAR Facilitates Autophagy and Exacerbates Pancreatic Fibrosis by Reducing Pre-miR-141 Maturation in Chronic Pancreatitis

    A novel lncRNA named long non-coding RNA (lncRNA) was found highly expressed in mouse and human chronic pancreatitis tissues.
    [Cell Death & Disease]

    Full Article

    YEATS2 Regulates the Activation of TAK1/NF-κB Pathway and Is Critical for Pancreatic Ductal Adenocarcinoma Cell Survival

    Constitutive activation of NF-κB is frequently observed in pancreatic ductal adenocarcinoma (PDAC). Scientists found that YEATS2, a scaffolding protein of ATAC complex, was highly expressed in human PDAC.
    [Cell Biology and Toxicology]

    AbstractGraphical Abstract

    The KRAS-Regulated Kinome Identifies WEE1 and ERK Co-Inhibition as a Potential Therapeutic Strategy in KRAS-Mutant Pancreatic Cancer

    Investigtors established a system-wide profile of the KRAS-regulated kinase signaling network in KRAS-mutant pancreatic ductal adenocarcinoma.
    [Journal of Biological Chemistry]

    Full Article

    Upregulating Sirtuin 6 Ameliorates Glycolysis, EMT and Distant Metastasis of Pancreatic Adenocarcinoma with Krüppel-Like Factor 10 Deficiency

    Correlations of KLF10 deficiency with rapid metastasis, elevated epithelial-mesenchymal transition, and glycolysis were demonstrated in resected pancreatic adenocarcinoma tissues, in vitro assays, and murine models.
    [Experimental & Molecular Medicine]

    Full Article

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    REVIEWS

    Metabolic Implications of Pancreatic Fat Accumulation

    Pancreatic fat is linked to reduced insulin secretion, at least under specific circumstances such as prediabetes, low BMI and increased genetic risk of type 2 diabetes mellitus. This review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation.
    [Nature Reviews Endocrinology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Provention Bio Announces Positive Interim Results from First-in-Human Study of Coxsackievirus B Vaccine Candidate PRV-101

    Provention Bio, Inc. announced positive interim results from PROVENT, a first-in-human study of PRV-101, a polyvalent inactivated coxsackievirus B vaccine candidate targeting all five key CVB strains associated with type 1 diabetes autoimmunity.
    [Provention Bio, Inc.]

    Press Release

    FEATURED EVENT

    2nd AACR-KCA Conference on Precision Medicine in Solid Tumors

    November 10 – 11, 2021
    Seoul, Korea & Online

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Type II Diabetes

    Harvard Medical School – Boston, Massachusettes, United States

    Postdoctoral position – Pancreatic Adenocarcinoma

    University of California Los Angeles – Los Angeles, California, United States

    Postdoctoral Fellow – Obesity, Diabetes and Cancer

    City of Hope – Duarte, California, United States

    Postdoctoral Associate – Neurobiology of Obesity and Diabetes

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Bioinformatics

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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