Pancreatic Cell News Volume 12. 43 | Nov 02 2021

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    2021-11-02 | PACN 12.43


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.43 – 2 November, 2021
    TOP STORY

    Single-Cell Analysis of the Human Pancreas in Type 2 Diabetes Using Multi-Spectral Imaging Mass Cytometry

    Investigators analyzed over two million cells from 16 pancreata obtained from donors with type 2 diabetes and 13 pancreata from age-similar non-diabetic controls.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Explore scientific events this November with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Therapeutic Effects of Acylated Ghrelin-Specific Receptor GHS-R1a Antagonist in Islet Transplantation

    Scientists elucidated whether regulation of growth hormone secretagogue receptor-1a (GHS-R1a), one of the ghrelin receptors, improved the therapeutic effects of islet transplantation using [D-Lys3]-GHRP-6, a specific GHS-R1a antagonist.
    [Scientific Reports]

    Full Article

    Cadmium Inhibits Signal Transducer and Activator of Transcription 6 Leading to Pancreatic β Cell Apoptosis

    The toxic heavy metal cadmium has been proven to cause pancreatic dysfunction and lead to the development of DM. Researchers investigated the effects of cadmium on the pancreatic β cell line MIN6 and explored the underlying mechanisms.
    [Endocrine Journal]

    Abstract

    Chemical Inducer of Regucalcin Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Pancreatic MIN6 β-Cells and RAW264.7 Macrophages

    Scientists reported that derrisfolin A induced the expression of endogenous regucalcin protein in both pancreatic MIN6 β-cells and RAW264.7 macrophages.
    [Febs Open Bio]

    Abstract

    Astragalus Polysaccharide Improve the Proliferation and Insulin Secretion of Mouse Pancreatic β Cells Induced by High Glucose and Palmitic Acid Partially through Promoting miR-136-5p and miR-149-5p Expression

    The effect of astragalus polysaccharide on dysfunctional insulin cells was investigated to clarify whether astragalus polysaccharide could be a novel drug for type 2 diabetes mellitus treatment.
    [Bioengineered]

    Full Article

    Pancreatic Cancer Cells Render Tumor-Associated Macrophages Metabolically Reprogrammed by a GARP and DNA Methylation-Mediated Mechanism

    Scientists conducted a study by employing a pancreatic ductal adenocarcinoma (PDA)-macrophage co-culture system, an “orthotopic” PDA syngeneic mouse model, and human PDA specimens, together with macrophages derived from GARP knockout mice and multiple analytic tools including whole-genome RNA sequencing,
    [Signal Transduction and Targeted Therapy]

    Full Article

    Morphological and p40 Immunohistochemical Analysis of Squamous Differentiation in Endoscopic Ultrasound Guided Fine Needle Biopsies of Pancreatic Ductal Adenocarcinoma

    Researchers assessed immunohistochemical p40 expression in fine needle biopsy samples with pancreatic ductal adenocarcinoma and association with cytomorphological features of squamous differentiation and clinical data.
    [Scientific Reports]

    Full Article

    4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine Induces Immunogenic Cell Death in Colon and Pancreatic Carcinoma Models as a Single Agent

    RNA sequencing experiments were conducted on PANC-1 human pancreatic cancer cells treated with docosahexaenoyl difluorodeoxycytidine (DHA–dFdC), dFdC, or vehicle control in vitro.
    [Cancer Chemotherapy and Pharmacology]

    Abstract

    Development and Evaluation of Icariin-Loaded PLGA-PEG Nanoparticles for Potentiation the Proapoptotic Activity in Pancreatic Cancer Cells

    Therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation approaches. Scientists showed that optimized formula enhanced cytotoxicity and apoptotic potential, compared with icariin-raw, against pancreatic cancer cell lines.
    [Aaps Pharmscitech]

    Abstract


    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Extracellular Vesicles in Pancreatic Cancer Progression and Therapies

    Scientists delineate the key factors in pancreatic ductal adenocarcinoma derived extracellular vesicles that mediate different tumour processes.
    [Cell Death & Disease]

    Full Article

    INDUSTRY AND POLICY NEWS

    Interpace Biosciences Announces US PTO Issuance of Patent No. 11,143,657 Titled: Topographic Genotyping for Determining the Diagnosis, Malignant Potential, and Biologic Behavior of Pancreatic Cysts and Related Conditions

    Interpace Biosciences, Inc. announced that the United States Patent and Trademark Office granted it a US patent titled: Topographic genotyping for determining the diagnosis, malignant potential, and biologic behavior of pancreatic cysts and related conditions.
    [Interpace Biosciences, Inc.]

    Press Release

    FEATURED EVENT

    American College of Toxicology Annual Meeting

    November 10 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Obesity and Metabolic Disorders

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Type II Diabetes

    Harvard Medical School – Boston, Massachusettes, United States

    Postdoctoral Position – Pancreatic Adenocarcinoma

    University of California Los Angeles – Los Angeles, California, United States

    Postdoctoral Associate – Neurobiology of Obesity and Diabetes

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Bioinformatics

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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